Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study
Breast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also affected. As an integrative approach, comparative oncology offers an opportunity to learn more about natural cancers in different species. M...
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MDPI AG
2020-09-01
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| Online Access: | https://www.mdpi.com/2076-2615/10/9/1652 |
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| author | Diana Dantas Liliana Soares Susana Novais Rui Vilarinho J. Agostinho Moreira Susana Silva Orlando Frazão Teresa Oliveira Nuno Leal Pedro Faísca Joana Reis |
| author_facet | Diana Dantas Liliana Soares Susana Novais Rui Vilarinho J. Agostinho Moreira Susana Silva Orlando Frazão Teresa Oliveira Nuno Leal Pedro Faísca Joana Reis |
| author_sort | Diana Dantas |
| collection | DOAJ |
| description | Breast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also affected. As an integrative approach, comparative oncology offers an opportunity to learn more about natural cancers in different species. Methods based on Raman spectroscopy have shown significant potential in the study of the human breast through the fingerprinting of biological tissue, which provides valuable information that can be used to identify, characterize and discriminate structures in breast tissue, in both healthy and carcinogenic environments. One of the most important applications of Raman spectroscopy in medical diagnosis is the characterization of microcalcifications, which are highly important diagnostic indicators of breast tissue diseases. Raman spectroscopy has been used to analyze the chemical composition of microcalcifications. These occur in benign and malignant lesions in the human breast, and Raman helps to discriminate microcalcifications as type I and type II according to their composition. This paper demonstrates the recent progress in understanding how this vibrational technique can discriminate through the fingerprint regions of lesions in unstained histology sections from canine mammary glands. |
| first_indexed | 2024-03-10T16:20:41Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T16:20:41Z |
| publishDate | 2020-09-01 |
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| series | Animals |
| spelling | doaj.art-881c920ea5584ef18f976a267ee757dc2023-11-20T13:43:42ZengMDPI AGAnimals2076-26152020-09-01109165210.3390/ani10091652Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot StudyDiana Dantas0Liliana Soares1Susana Novais2Rui Vilarinho3J. Agostinho Moreira4Susana Silva5Orlando Frazão6Teresa Oliveira7Nuno Leal8Pedro Faísca9Joana Reis10IFIMUP, Department of Physics and Astronomy, Faculty of Sciences of University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, PortugalIFIMUP, Department of Physics and Astronomy, Faculty of Sciences of University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, PortugalINESC TEC—Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, PortugalIFIMUP, Department of Physics and Astronomy, Faculty of Sciences of University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, PortugalIFIMUP, Department of Physics and Astronomy, Faculty of Sciences of University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, PortugalINESC TEC—Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, PortugalINESC TEC—Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, PortugalDepartamento de Medicina Veterinária; Escola de Ciências e Tecnologia; Universidade de Évora; Pólo da Mitra, Apartado 94, 7002-554 Évora, PortugalDNAtech Laboratório Veterinário, Estrada do Paço do Lumiar, N.° 22 Edifício E, 1° Andar, 1649-038 Lisboa, PortugalDNAtech Laboratório Veterinário, Estrada do Paço do Lumiar, N.° 22 Edifício E, 1° Andar, 1649-038 Lisboa, PortugalDepartamento de Medicina Veterinária; Escola de Ciências e Tecnologia; Universidade de Évora; Pólo da Mitra, Apartado 94, 7002-554 Évora, PortugalBreast cancer is a health problem that affects individual life quality and the family system. It is the most frequent type of cancer in women, but men are also affected. As an integrative approach, comparative oncology offers an opportunity to learn more about natural cancers in different species. Methods based on Raman spectroscopy have shown significant potential in the study of the human breast through the fingerprinting of biological tissue, which provides valuable information that can be used to identify, characterize and discriminate structures in breast tissue, in both healthy and carcinogenic environments. One of the most important applications of Raman spectroscopy in medical diagnosis is the characterization of microcalcifications, which are highly important diagnostic indicators of breast tissue diseases. Raman spectroscopy has been used to analyze the chemical composition of microcalcifications. These occur in benign and malignant lesions in the human breast, and Raman helps to discriminate microcalcifications as type I and type II according to their composition. This paper demonstrates the recent progress in understanding how this vibrational technique can discriminate through the fingerprint regions of lesions in unstained histology sections from canine mammary glands.https://www.mdpi.com/2076-2615/10/9/1652breast cancerhistopathologymicrocalcificationcaninecomparative oncologyRaman spectroscopy |
| spellingShingle | Diana Dantas Liliana Soares Susana Novais Rui Vilarinho J. Agostinho Moreira Susana Silva Orlando Frazão Teresa Oliveira Nuno Leal Pedro Faísca Joana Reis Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study Animals breast cancer histopathology microcalcification canine comparative oncology Raman spectroscopy |
| title | Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study |
| title_full | Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study |
| title_fullStr | Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study |
| title_full_unstemmed | Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study |
| title_short | Discrimination of Benign and Malignant Lesions in Canine Mammary Tissue Samples Using Raman Spectroscopy: A Pilot Study |
| title_sort | discrimination of benign and malignant lesions in canine mammary tissue samples using raman spectroscopy a pilot study |
| topic | breast cancer histopathology microcalcification canine comparative oncology Raman spectroscopy |
| url | https://www.mdpi.com/2076-2615/10/9/1652 |
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