Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life
Purpose Bladder cancer is a complex disease with a wide range of outcomes. Clinicopathological factors only partially explain the variability between patients in prognosis and treatment response. There is a need for large cohorts collecting extensive data and biological samples to: (1) investigate g...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| 格式: | 文件 |
| 语言: | English |
| 出版: |
BMJ Publishing Group
2023-12-01
|
| 丛编: | BMJ Open |
| 在线阅读: | https://bmjopen.bmj.com/content/13/12/e075942.full |
| _version_ | 1827394236314550272 |
|---|---|
| author | Simone Benhamou Julia Bonastre Bijan Ghaleh Hélène Blanché Pascal Eschwege Arnauld Villers Arnaud Méjean François Radvanyi Xavier Rébillard Yves Allory Thierry Lebret Aldéric Fraslin Yann Neuzillet Stéphane Droupy Dimitri Vordos Laurent Guy Marc Schneider Patrick Coloby Jean Lacoste Jacques Lacoste Jean-Luc Descotes Guillaume Loison Odette Mariani Anthony Mangin Nanor Sirab Karine Groussard |
| author_facet | Simone Benhamou Julia Bonastre Bijan Ghaleh Hélène Blanché Pascal Eschwege Arnauld Villers Arnaud Méjean François Radvanyi Xavier Rébillard Yves Allory Thierry Lebret Aldéric Fraslin Yann Neuzillet Stéphane Droupy Dimitri Vordos Laurent Guy Marc Schneider Patrick Coloby Jean Lacoste Jacques Lacoste Jean-Luc Descotes Guillaume Loison Odette Mariani Anthony Mangin Nanor Sirab Karine Groussard |
| author_sort | Simone Benhamou |
| collection | DOAJ |
| description | Purpose Bladder cancer is a complex disease with a wide range of outcomes. Clinicopathological factors only partially explain the variability between patients in prognosis and treatment response. There is a need for large cohorts collecting extensive data and biological samples to: (1) investigate gene-environment interactions, pathological/molecular classification and biomarker discovery; and (2) describe treatment patterns, outcomes, resource use and quality of life in a real-world setting.Participants COBLAnCE (COhort to study BLAdder CancEr) is a French national prospective cohort of patients with bladder cancer recruited between 2012 and 2018 and followed for 6 years. Data on patient and tumour characteristics, treatments, outcomes and biological samples are collected at enrolment and during the follow-up.Findings to date We describe the cohort at enrolment according to baseline surgery and tumour type. In total, 1800 patients were included: 1114 patients with non-muscle-invasive bladder cancer (NMIBC) and 76 patients with muscle-invasive bladder cancer (MIBC) had transurethral resection of a bladder tumour without cystectomy, and 610 patients with NMIBC or MIBC underwent cystectomy. Most patients had a solitary lesion (56.3%) without basement membrane invasion (71.7% of Ta and/or Tis). Half of the patients with cystectomy were stage ≤T2 and 60% had non-continent diversion. Surgery included local (n=298) or super-extended lymph node dissections (n=11) and prostate removal (n=492). Among women, 16.5% underwent cystectomy and 81.4% anterior pelvectomy.Future plans COBLAnCE will be used for long-term studies of bladder cancer with focus on clinicopathological factors and molecular markers. It will lead to a much-needed improvement in the understanding of the disease. The cohort provides valuable real-world data, enabling researchers to study various research questions, assess routine medical practices and guide medical decision-making. |
| first_indexed | 2024-03-08T18:07:37Z |
| format | Article |
| id | doaj.art-881caa5cd4ae4746bcdbd15266359a45 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-08T18:07:37Z |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-881caa5cd4ae4746bcdbd15266359a452024-01-01T14:55:08ZengBMJ Publishing GroupBMJ Open2044-60552023-12-01131210.1136/bmjopen-2023-075942Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of lifeSimone Benhamou0Julia Bonastre1Bijan Ghaleh2Hélène Blanché3Pascal Eschwege4Arnauld Villers5Arnaud Méjean6François Radvanyi7Xavier Rébillard8Yves Allory9Thierry Lebret10Aldéric Fraslin11Yann Neuzillet12Stéphane Droupy13Dimitri Vordos14Laurent Guy15Marc Schneider16Patrick Coloby17Jean Lacoste18Jacques Lacoste19Jean-Luc Descotes20Guillaume Loison21Odette Mariani22Anthony Mangin23Nanor Sirab24Karine Groussard2527INSERM U 946, Paris, France3Gustave Roussy, Service de Biostatistique et d`Epidemiologie, Villejuif, France9AP-HP, Hôpital Henri-Mondor, Plateforme de Ressources Biologiques, Créteil, France6Fondation Jean Dausset-CEPH, Paris, FranceService d`Urologie, CHU Bradois, Vandoeuvre-Lès-Nancy, France5 Department of Urology, CHU Lille, University Lille Nord de France, Lille, FranceUrology, Hopital Europeen Georges Pompidou, Paris, FranceInstitut Curie, Centre de recherche, Paris, France2Service Urologie, Clinique Beau Soleil, Montpellier, Occitanie, FranceDepartment of Pathology, Université Paris-Saclay, Institut Curie, Paris, FranceUrology, Hôpital Foch, Suresnes, FranceBiostatistics and Epidemiology, Gustave Roussy, Villejuif, FranceUrology, Hôpital Foch, Suresnes, FranceUrology, Centre Hospitalier Universitaire de Nimes, Nimes, FranceClinical Investigation Center 1430, INSERM, Créteil, FranceUrology, University Hospital Centre Gabriel Montpied, Clermont-Ferrand, FranceUrology, Hopitaux Civils de Colmar, Colmar, FranceUrology, University Hospital Center René Dubos, Cergy-Pontoise, FranceUrology, Private Hospital of Provence, Aix-en-Provence, FranceUrology, Atlantis Clinic, Saint-Herblain, FranceUrology, CHU Grenoble Alpes, Grenoble, FranceUrology, la Croix du Sud Clinic, Quint Fonsegrives, FranceBiological Resources Center, Curie Institute Hospital Group, Paris, FranceBiostatistics and Epidemiology, Gustave Roussy, Villejuif, FrancePathology, Curie Institute, Paris, FranceU1018, INSERM, Villejuif, FrancePurpose Bladder cancer is a complex disease with a wide range of outcomes. Clinicopathological factors only partially explain the variability between patients in prognosis and treatment response. There is a need for large cohorts collecting extensive data and biological samples to: (1) investigate gene-environment interactions, pathological/molecular classification and biomarker discovery; and (2) describe treatment patterns, outcomes, resource use and quality of life in a real-world setting.Participants COBLAnCE (COhort to study BLAdder CancEr) is a French national prospective cohort of patients with bladder cancer recruited between 2012 and 2018 and followed for 6 years. Data on patient and tumour characteristics, treatments, outcomes and biological samples are collected at enrolment and during the follow-up.Findings to date We describe the cohort at enrolment according to baseline surgery and tumour type. In total, 1800 patients were included: 1114 patients with non-muscle-invasive bladder cancer (NMIBC) and 76 patients with muscle-invasive bladder cancer (MIBC) had transurethral resection of a bladder tumour without cystectomy, and 610 patients with NMIBC or MIBC underwent cystectomy. Most patients had a solitary lesion (56.3%) without basement membrane invasion (71.7% of Ta and/or Tis). Half of the patients with cystectomy were stage ≤T2 and 60% had non-continent diversion. Surgery included local (n=298) or super-extended lymph node dissections (n=11) and prostate removal (n=492). Among women, 16.5% underwent cystectomy and 81.4% anterior pelvectomy.Future plans COBLAnCE will be used for long-term studies of bladder cancer with focus on clinicopathological factors and molecular markers. It will lead to a much-needed improvement in the understanding of the disease. The cohort provides valuable real-world data, enabling researchers to study various research questions, assess routine medical practices and guide medical decision-making.https://bmjopen.bmj.com/content/13/12/e075942.full |
| spellingShingle | Simone Benhamou Julia Bonastre Bijan Ghaleh Hélène Blanché Pascal Eschwege Arnauld Villers Arnaud Méjean François Radvanyi Xavier Rébillard Yves Allory Thierry Lebret Aldéric Fraslin Yann Neuzillet Stéphane Droupy Dimitri Vordos Laurent Guy Marc Schneider Patrick Coloby Jean Lacoste Jacques Lacoste Jean-Luc Descotes Guillaume Loison Odette Mariani Anthony Mangin Nanor Sirab Karine Groussard Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life BMJ Open |
| title | Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life |
| title_full | Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life |
| title_fullStr | Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life |
| title_full_unstemmed | Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life |
| title_short | Cohort profile: COBLAnCE: a French prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real-world data on treatment patterns, resource use and quality of life |
| title_sort | cohort profile coblance a french prospective cohort to study prognostic and predictive factors in bladder cancer and to generate real world data on treatment patterns resource use and quality of life |
| url | https://bmjopen.bmj.com/content/13/12/e075942.full |
| work_keys_str_mv | AT simonebenhamou cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT juliabonastre cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT bijanghaleh cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT heleneblanche cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT pascaleschwege cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT arnauldvillers cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT arnaudmejean cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT francoisradvanyi cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT xavierrebillard cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT yvesallory cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT thierrylebret cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT aldericfraslin cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT yannneuzillet cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT stephanedroupy cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT dimitrivordos cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT laurentguy cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT marcschneider cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT patrickcoloby cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT jeanlacoste cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT jacqueslacoste cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT jeanlucdescotes cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT guillaumeloison cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT odettemariani cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT anthonymangin cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT nanorsirab cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife AT karinegroussard cohortprofilecoblanceafrenchprospectivecohorttostudyprognosticandpredictivefactorsinbladdercancerandtogeneraterealworlddataontreatmentpatternsresourceuseandqualityoflife |