Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue
Signal Transducer and Activator of Transcription (STAT) proteins have been identified as drivers of prostate cancer (PCa) progression and development of aggressive castration-resistant phenotypes. In particular, STAT3, 5, and 6 have been linked to resistance to androgen receptor inhibition and metas...
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MDPI AG
2022-02-01
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| Online adgang: | https://www.mdpi.com/2075-1729/12/2/240 |
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| author | Celina Ebersbach Alicia-Marie K. Beier Pia Hönscheid Christian Sperling Korinna Jöhrens Gustavo B. Baretton Christian Thomas Ulrich Sommer Angelika Borkowetz Holger H. H. Erb |
| author_facet | Celina Ebersbach Alicia-Marie K. Beier Pia Hönscheid Christian Sperling Korinna Jöhrens Gustavo B. Baretton Christian Thomas Ulrich Sommer Angelika Borkowetz Holger H. H. Erb |
| author_sort | Celina Ebersbach |
| collection | DOAJ |
| description | Signal Transducer and Activator of Transcription (STAT) proteins have been identified as drivers of prostate cancer (PCa) progression and development of aggressive castration-resistant phenotypes. In particular, STAT3, 5, and 6 have been linked to resistance to androgen receptor inhibition and metastasis in in vitro and in vivo models. This descriptive study aimed to validate these preclinical data in tissue obtained from patients with PCa before and while under androgen-deprivation therapy. Therefore, STAT3, 5, and 6 expressions and activity were assessed by immunohistochemistry. The data revealed that STAT3 and 5 changed in PCa. However, there was no relationship between expression and survival. Moreover, due to the heterogeneous nature of PCa, the preclinical results could not be transferred congruently to the patient’s material. A pilot study with a longitudinal patient cohort could also show this heterogeneous influence of systemic therapy on STAT3, 5, and 6 expressions and activity. Even if the main mechanisms were validated, these data demonstrate the urge for better patient-near preclinical models. Therefore, these data reflect the need for investigations of STAT proteins in a longitudinal patient cohort to identify factors responsible for the diverse influence of system therapy on STAT expression. |
| first_indexed | 2024-03-09T21:35:30Z |
| format | Article |
| id | doaj.art-881d12c967dc484f93f7a32fe6c22fb7 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T21:35:30Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-881d12c967dc484f93f7a32fe6c22fb72023-11-23T20:46:17ZengMDPI AGLife2075-17292022-02-0112224010.3390/life12020240Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer TissueCelina Ebersbach0Alicia-Marie K. Beier1Pia Hönscheid2Christian Sperling3Korinna Jöhrens4Gustavo B. Baretton5Christian Thomas6Ulrich Sommer7Angelika Borkowetz8Holger H. H. Erb9Department of Urology, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Urology, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Pathology, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, GermanyInstitute of Pathology, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, GermanyInstitute of Pathology, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, GermanyInstitute of Pathology, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, GermanyDepartment of Urology, Technische Universität Dresden, 01307 Dresden, GermanyInstitute of Pathology, Universitätsklinikum Carl Gustav Carus Dresden, 01307 Dresden, GermanyDepartment of Urology, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Urology, Technische Universität Dresden, 01307 Dresden, GermanySignal Transducer and Activator of Transcription (STAT) proteins have been identified as drivers of prostate cancer (PCa) progression and development of aggressive castration-resistant phenotypes. In particular, STAT3, 5, and 6 have been linked to resistance to androgen receptor inhibition and metastasis in in vitro and in vivo models. This descriptive study aimed to validate these preclinical data in tissue obtained from patients with PCa before and while under androgen-deprivation therapy. Therefore, STAT3, 5, and 6 expressions and activity were assessed by immunohistochemistry. The data revealed that STAT3 and 5 changed in PCa. However, there was no relationship between expression and survival. Moreover, due to the heterogeneous nature of PCa, the preclinical results could not be transferred congruently to the patient’s material. A pilot study with a longitudinal patient cohort could also show this heterogeneous influence of systemic therapy on STAT3, 5, and 6 expressions and activity. Even if the main mechanisms were validated, these data demonstrate the urge for better patient-near preclinical models. Therefore, these data reflect the need for investigations of STAT proteins in a longitudinal patient cohort to identify factors responsible for the diverse influence of system therapy on STAT expression.https://www.mdpi.com/2075-1729/12/2/240STAT3STAT5STAT6androgen deprivation therapynovel hormonal therapychemotherapy |
| spellingShingle | Celina Ebersbach Alicia-Marie K. Beier Pia Hönscheid Christian Sperling Korinna Jöhrens Gustavo B. Baretton Christian Thomas Ulrich Sommer Angelika Borkowetz Holger H. H. Erb Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue Life STAT3 STAT5 STAT6 androgen deprivation therapy novel hormonal therapy chemotherapy |
| title | Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue |
| title_full | Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue |
| title_fullStr | Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue |
| title_full_unstemmed | Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue |
| title_short | Influence of Systemic Therapy on the Expression and Activity of Selected STAT Proteins in Prostate Cancer Tissue |
| title_sort | influence of systemic therapy on the expression and activity of selected stat proteins in prostate cancer tissue |
| topic | STAT3 STAT5 STAT6 androgen deprivation therapy novel hormonal therapy chemotherapy |
| url | https://www.mdpi.com/2075-1729/12/2/240 |
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