Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor
Abstract Background Overwhelming Fe accumulation in tumor arouses strong oxidative stress. To benefit the cancer patients, Fe(II) delivered by carbon nanoparticles-Fe(II) complex (CNSI-Fe) should be visualized to ensure the successful intratumoral injection and the antitumor mechanisms should be inv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Cancer Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12645-023-00196-5 |
| _version_ | 1797841156034265088 |
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| author | Ping Xie Yuanfang Huang Kexin Tang Xian Wu Cheng Zeng Sheng-Tao Yang Xiaohai Tang |
| author_facet | Ping Xie Yuanfang Huang Kexin Tang Xian Wu Cheng Zeng Sheng-Tao Yang Xiaohai Tang |
| author_sort | Ping Xie |
| collection | DOAJ |
| description | Abstract Background Overwhelming Fe accumulation in tumor arouses strong oxidative stress. To benefit the cancer patients, Fe(II) delivered by carbon nanoparticles-Fe(II) complex (CNSI-Fe) should be visualized to ensure the successful intratumoral injection and the antitumor mechanisms should be investigated at molecular level. Results Intracellular Fe accumulations associating with the uptakes of CNSI-Fe were observed both in vitro and in vivo. The retention of Fe(II) in tumor over 72 h was visualized by magnetic resonance imaging. CNSI-Fe inhibited the tumor growth and expanded the lifespan of colonic tumor-bearing mice. The antitumor activity of CNSI-Fe was attributed to the increases of OH radicals and the oxidative stress in tumor cells, which resulted in cell apoptosis and ferroptosis. The transcriptome analyses confirmed the changes of ferroptosis and inflammation signaling pathways by CNSI-Fe treatment. The low toxicity of CNSI-Fe was indicated by the serum biochemistry, hematology, and histopathology. Conclusion CNSI-Fe induced the efficient apoptosis and ferroptosis of colonic tumor for cancer therapy. Our results would benefit the clinical applications of CNSI-Fe and stimulate great interest in the nanomedicine. |
| first_indexed | 2024-04-09T16:26:30Z |
| format | Article |
| id | doaj.art-881d148168d7441fa8f6efd113dbf175 |
| institution | Directory Open Access Journal |
| issn | 1868-6958 1868-6966 |
| language | English |
| last_indexed | 2024-04-09T16:26:30Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Nanotechnology |
| spelling | doaj.art-881d148168d7441fa8f6efd113dbf1752023-04-23T11:09:35ZengBMCCancer Nanotechnology1868-69581868-69662023-04-0114111610.1186/s12645-023-00196-5Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumorPing Xie0Yuanfang Huang1Kexin Tang2Xian Wu3Cheng Zeng4Sheng-Tao Yang5Xiaohai Tang6State Key Laboratory of Oral Diseases, West China, College of Stomatology, Sichuan UniversitySichuan Enray Pharmaceutical Sciences CompanySichuan Enray Pharmaceutical Sciences CompanyKey Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu UniversitySichuan Enray Pharmaceutical Sciences CompanyKey Laboratory of Pollution Control Chemistry and Environmental Functional Materials for Qinghai-Tibet Plateau of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu UniversitySichuan Enray Pharmaceutical Sciences CompanyAbstract Background Overwhelming Fe accumulation in tumor arouses strong oxidative stress. To benefit the cancer patients, Fe(II) delivered by carbon nanoparticles-Fe(II) complex (CNSI-Fe) should be visualized to ensure the successful intratumoral injection and the antitumor mechanisms should be investigated at molecular level. Results Intracellular Fe accumulations associating with the uptakes of CNSI-Fe were observed both in vitro and in vivo. The retention of Fe(II) in tumor over 72 h was visualized by magnetic resonance imaging. CNSI-Fe inhibited the tumor growth and expanded the lifespan of colonic tumor-bearing mice. The antitumor activity of CNSI-Fe was attributed to the increases of OH radicals and the oxidative stress in tumor cells, which resulted in cell apoptosis and ferroptosis. The transcriptome analyses confirmed the changes of ferroptosis and inflammation signaling pathways by CNSI-Fe treatment. The low toxicity of CNSI-Fe was indicated by the serum biochemistry, hematology, and histopathology. Conclusion CNSI-Fe induced the efficient apoptosis and ferroptosis of colonic tumor for cancer therapy. Our results would benefit the clinical applications of CNSI-Fe and stimulate great interest in the nanomedicine.https://doi.org/10.1186/s12645-023-00196-5Carbon nanoparticlesFerrous ironAntitumor activityFerroptosisMagnetic resonance imaging |
| spellingShingle | Ping Xie Yuanfang Huang Kexin Tang Xian Wu Cheng Zeng Sheng-Tao Yang Xiaohai Tang Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor Cancer Nanotechnology Carbon nanoparticles Ferrous iron Antitumor activity Ferroptosis Magnetic resonance imaging |
| title | Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor |
| title_full | Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor |
| title_fullStr | Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor |
| title_full_unstemmed | Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor |
| title_short | Carbon nanoparticles-Fe(II) complex for efficient theranostics of xenografted colonic tumor |
| title_sort | carbon nanoparticles fe ii complex for efficient theranostics of xenografted colonic tumor |
| topic | Carbon nanoparticles Ferrous iron Antitumor activity Ferroptosis Magnetic resonance imaging |
| url | https://doi.org/10.1186/s12645-023-00196-5 |
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