Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175

Transmembrane protein 175 (TMEM175) is a K+-selective ion channel expressed in lysosomal membranes, where it establishes a membrane potential essential for lysosomal function and its dysregulation is associated with the development of Parkinson’s Disease. TMEM175 is evolutionarily distinct from all...

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Bibliographic Details
Main Authors: SeCheol Oh, Navid Paknejad, Richard K Hite
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
potassium channel
ion channel
electron microscopy
Online Access:https://elifesciences.org/articles/53430

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