Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML

Abstract Over the last 50 years, there has been a steady improvement in the treatment outcome of acute myeloid leukemia (AML). However, median survival in the elderly is still poor due to intolerance to intensive chemotherapy and higher numbers of patients with adverse cytogenetics. Fadraciclib (CYC...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wittawat Chantkran, Ya-Ching Hsieh, Daniella Zheleva, Sheelagh Frame, Helen Wheadon, Mhairi Copland
التنسيق: مقال
اللغة:English
منشور في: Nature Publishing Group 2021-06-01
سلاسل:Cell Death Discovery
الوصول للمادة أونلاين:https://doi.org/10.1038/s41420-021-00496-y