Lysosomes, Lysosomal Storage Diseases, and Inflammation
Lysosomes were originally described in the early 1950s by de Duve who was also the first to recognize the importance of these organelles in human disease. We know now that lysosomes are involved in numerous biological processes, and abnormalities in lysosomal function may result in a broad range of...
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| Format: | Article |
| Language: | English |
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SciELO
2016-05-01
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| Series: | Journal of Inborn Errors of Metabolism and Screening |
| Online Access: | https://doi.org/10.1177/2326409816650465 |
| _version_ | 1818807110587121664 |
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| author | Calogera M. Simonaro PhD |
| author_facet | Calogera M. Simonaro PhD |
| author_sort | Calogera M. Simonaro PhD |
| collection | DOAJ |
| description | Lysosomes were originally described in the early 1950s by de Duve who was also the first to recognize the importance of these organelles in human disease. We know now that lysosomes are involved in numerous biological processes, and abnormalities in lysosomal function may result in a broad range of diseases. This review will briefly discuss the role of lysosomes in inflammation and how disruption of normal lysosomal function in the lysosomal storage diseases (LSDs) leads to abnormalities in inflammation and immunity. |
| first_indexed | 2024-12-18T19:20:27Z |
| format | Article |
| id | doaj.art-88205e8a7ffc4881942a9c8486ad58b4 |
| institution | Directory Open Access Journal |
| issn | 2326-4594 |
| language | English |
| last_indexed | 2024-12-18T19:20:27Z |
| publishDate | 2016-05-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Inborn Errors of Metabolism and Screening |
| spelling | doaj.art-88205e8a7ffc4881942a9c8486ad58b42022-12-21T20:56:01ZengSciELOJournal of Inborn Errors of Metabolism and Screening2326-45942016-05-01410.1177/232640981665046510.1177_2326409816650465Lysosomes, Lysosomal Storage Diseases, and InflammationCalogera M. Simonaro PhD0Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY USALysosomes were originally described in the early 1950s by de Duve who was also the first to recognize the importance of these organelles in human disease. We know now that lysosomes are involved in numerous biological processes, and abnormalities in lysosomal function may result in a broad range of diseases. This review will briefly discuss the role of lysosomes in inflammation and how disruption of normal lysosomal function in the lysosomal storage diseases (LSDs) leads to abnormalities in inflammation and immunity.https://doi.org/10.1177/2326409816650465 |
| spellingShingle | Calogera M. Simonaro PhD Lysosomes, Lysosomal Storage Diseases, and Inflammation Journal of Inborn Errors of Metabolism and Screening |
| title | Lysosomes, Lysosomal Storage Diseases, and Inflammation |
| title_full | Lysosomes, Lysosomal Storage Diseases, and Inflammation |
| title_fullStr | Lysosomes, Lysosomal Storage Diseases, and Inflammation |
| title_full_unstemmed | Lysosomes, Lysosomal Storage Diseases, and Inflammation |
| title_short | Lysosomes, Lysosomal Storage Diseases, and Inflammation |
| title_sort | lysosomes lysosomal storage diseases and inflammation |
| url | https://doi.org/10.1177/2326409816650465 |
| work_keys_str_mv | AT calogeramsimonarophd lysosomeslysosomalstoragediseasesandinflammation |