Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer
The abnormal expression of long non-coding RNAs(lncRNAs) is closely related to the prognosis of patients. This finding may indicate a new target for the treatment of malignant tumors. Non-muscle invasive bladder cancer (NMIBC) is the most common subtype of bladder cancer, and BCG intravesical therap...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/8/1462 |
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| author | Zhiquan Hu Siquan Ma Yi Sun Gongwei Long Ke Chen |
| author_facet | Zhiquan Hu Siquan Ma Yi Sun Gongwei Long Ke Chen |
| author_sort | Zhiquan Hu |
| collection | DOAJ |
| description | The abnormal expression of long non-coding RNAs(lncRNAs) is closely related to the prognosis of patients. This finding may indicate a new target for the treatment of malignant tumors. Non-muscle invasive bladder cancer (NMIBC) is the most common subtype of bladder cancer, and BCG intravesical therapy is the first-line treatment for NMIBC, but about half of NMIBC patients relapse within two years after BCG treatment. Therefore, it is necessary to screen out lncRNAs related to the prognosis and treatment of BGC-resistant patients. Here, we performed differential expression analysis of lncRNAs in the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, and screened <i>MIR4435-2HG</i> as the only BCG-response-related lncRNA. Then, the prognosis value of <i>MIR4435-2HG</i> was validated in several publicly available cohorts, and confirmed its prognostic value in bladder cancer of different stages. In addition, we also analyzed its genetic alterations, clinical relevance, function enrichment, and association with other biomarkers. Further validation of the expression of <i>MIR4435-2HG</i> might be helpful to instruct NMIBC prognosis and treatment. |
| first_indexed | 2024-03-09T04:24:02Z |
| format | Article |
| id | doaj.art-8822050c3b2040d0b62f5018f30a9c33 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T04:24:02Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-8822050c3b2040d0b62f5018f30a9c332023-12-03T13:43:21ZengMDPI AGGenes2073-44252022-08-01138146210.3390/genes13081462Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder CancerZhiquan Hu0Siquan Ma1Yi Sun2Gongwei Long3Ke Chen4Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaThe abnormal expression of long non-coding RNAs(lncRNAs) is closely related to the prognosis of patients. This finding may indicate a new target for the treatment of malignant tumors. Non-muscle invasive bladder cancer (NMIBC) is the most common subtype of bladder cancer, and BCG intravesical therapy is the first-line treatment for NMIBC, but about half of NMIBC patients relapse within two years after BCG treatment. Therefore, it is necessary to screen out lncRNAs related to the prognosis and treatment of BGC-resistant patients. Here, we performed differential expression analysis of lncRNAs in the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, and screened <i>MIR4435-2HG</i> as the only BCG-response-related lncRNA. Then, the prognosis value of <i>MIR4435-2HG</i> was validated in several publicly available cohorts, and confirmed its prognostic value in bladder cancer of different stages. In addition, we also analyzed its genetic alterations, clinical relevance, function enrichment, and association with other biomarkers. Further validation of the expression of <i>MIR4435-2HG</i> might be helpful to instruct NMIBC prognosis and treatment.https://www.mdpi.com/2073-4425/13/8/1462bladder cancerlncRNAprognosisBCGbiomarkers |
| spellingShingle | Zhiquan Hu Siquan Ma Yi Sun Gongwei Long Ke Chen Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer Genes bladder cancer lncRNA prognosis BCG biomarkers |
| title | Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer |
| title_full | Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer |
| title_fullStr | Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer |
| title_full_unstemmed | Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer |
| title_short | Identification of Long Non-Coding RNA MIR4435-2HG as a Prognostic Biomarker in Bladder Cancer |
| title_sort | identification of long non coding rna mir4435 2hg as a prognostic biomarker in bladder cancer |
| topic | bladder cancer lncRNA prognosis BCG biomarkers |
| url | https://www.mdpi.com/2073-4425/13/8/1462 |
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