Co-Administration of Lipid Nanoparticles and Sub-Unit Vaccine Antigens Is Required for Increase in Antigen-Specific Immune Responses in Mice

Co-Administration of Lipid Nanoparticles and Sub-Unit Vaccine Antigens Is Required for Increase in Antigen-Specific Immune Responses in Mice

A vast body of evidence suggests that nanoparticles function as potent immune-modulatory agents. We have previously shown that Merck proprietary Lipid NanoParticles (LNPs) markedly boost B-cell and T-cell responses to sub-unit vaccine antigens in mice. To further evaluate the specifics of vaccine de...

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Bibliographic Details
Main Authors: Elizabeth A. Thoryk, Gokul Swaminathan, Steven Meschino, Kara S. Cox, Marian Gindy, Danilo R. Casimiro, Andrew J. Bett
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Vaccines
Subjects:
vaccines
lipid nanoparticles
formulation
alum
adjuvants
Online Access:http://www.mdpi.com/2076-393X/4/4/47

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