Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation

Nicotinamide reverses deficits in puberty-born neurons and cognitive function after maternal separation

Abstract Background Early life stress (ELS) is associated with the development of schizophrenia later in life. The hippocampus develops significantly during childhood and is extremely reactive to stress. In rodent models, ELS can induce neuroinflammation, hippocampal neuronal loss, and schizophrenia...

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Bibliographic Details
Main Authors: Keke Hao, Huiling Wang, Yuejin Zhang, Xinhui Xie, Huan Huang, Cheng Chen, Shilin Xu, Rui Xu, Chang Shu, Zhongchun Liu, Yuan Zhou, Gavin P. Reynolds, Gaohua Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Neuroinflammation
Subjects:
Schizophrenia
Early life stress
Maternal separation
Cognitive impairment
Neuroinflammation
Neuronal loss
Online Access:https://doi.org/10.1186/s12974-022-02591-y

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