Potential crosstalk between pericytes and cathepsins in the tumour microenvironment
Cancer remains a formidable global health challenge, and as such, investigators are constantly exploring underlying mechanisms that drive its progression. One area of interest is the role of lysosomal enzymes, such as cathepsins, in regulating cancer growth and development in the tumour microenviron...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223007229 |
| _version_ | 1797801852056633344 |
|---|---|
| author | A. Mustafa F. Elkhamisy N. Arghiani M.Z.I. Pranjol |
| author_facet | A. Mustafa F. Elkhamisy N. Arghiani M.Z.I. Pranjol |
| author_sort | A. Mustafa |
| collection | DOAJ |
| description | Cancer remains a formidable global health challenge, and as such, investigators are constantly exploring underlying mechanisms that drive its progression. One area of interest is the role of lysosomal enzymes, such as cathepsins, in regulating cancer growth and development in the tumour microenvironment (TME). Pericytes, a key component of vasculature, play a key role in regulating blood vessel formation in the TME, have been shown to be influenced by cathepsins and their activity. Although cathepsins such as cathepsins D and L have been shown to induce angiogenesis, currently no direct link is known between pericytes and cathepsins interaction. This review aims to shed light on the potential interplay between pericytes and cathepsins in the TME, highlighting the possible implications for cancer therapy and future research directions. |
| first_indexed | 2024-03-13T04:56:50Z |
| format | Article |
| id | doaj.art-882b44a1e881481c9b6f4f91aeb17975 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T04:56:50Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-882b44a1e881481c9b6f4f91aeb179752023-06-18T05:00:45ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-08-01164114932Potential crosstalk between pericytes and cathepsins in the tumour microenvironmentA. Mustafa0F. Elkhamisy1N. Arghiani2M.Z.I. Pranjol3School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UKSchool of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UKSchool of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; Corresponding author at: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK; Corresponding author.Cancer remains a formidable global health challenge, and as such, investigators are constantly exploring underlying mechanisms that drive its progression. One area of interest is the role of lysosomal enzymes, such as cathepsins, in regulating cancer growth and development in the tumour microenvironment (TME). Pericytes, a key component of vasculature, play a key role in regulating blood vessel formation in the TME, have been shown to be influenced by cathepsins and their activity. Although cathepsins such as cathepsins D and L have been shown to induce angiogenesis, currently no direct link is known between pericytes and cathepsins interaction. This review aims to shed light on the potential interplay between pericytes and cathepsins in the TME, highlighting the possible implications for cancer therapy and future research directions.http://www.sciencedirect.com/science/article/pii/S0753332223007229CathepsinsPericytesEndothelial cellsAngiogenesisTumour microenvironmentCancer |
| spellingShingle | A. Mustafa F. Elkhamisy N. Arghiani M.Z.I. Pranjol Potential crosstalk between pericytes and cathepsins in the tumour microenvironment Biomedicine & Pharmacotherapy Cathepsins Pericytes Endothelial cells Angiogenesis Tumour microenvironment Cancer |
| title | Potential crosstalk between pericytes and cathepsins in the tumour microenvironment |
| title_full | Potential crosstalk between pericytes and cathepsins in the tumour microenvironment |
| title_fullStr | Potential crosstalk between pericytes and cathepsins in the tumour microenvironment |
| title_full_unstemmed | Potential crosstalk between pericytes and cathepsins in the tumour microenvironment |
| title_short | Potential crosstalk between pericytes and cathepsins in the tumour microenvironment |
| title_sort | potential crosstalk between pericytes and cathepsins in the tumour microenvironment |
| topic | Cathepsins Pericytes Endothelial cells Angiogenesis Tumour microenvironment Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223007229 |
| work_keys_str_mv | AT amustafa potentialcrosstalkbetweenpericytesandcathepsinsinthetumourmicroenvironment AT felkhamisy potentialcrosstalkbetweenpericytesandcathepsinsinthetumourmicroenvironment AT narghiani potentialcrosstalkbetweenpericytesandcathepsinsinthetumourmicroenvironment AT mzipranjol potentialcrosstalkbetweenpericytesandcathepsinsinthetumourmicroenvironment |