Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line

Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line

<p>Abstract</p> <p>Background</p> <p>Cancer cell migration is fundamentally required for breast tumour invasion and metastasis. The insulin-like growth factor 1 tyrosine kinase receptor (IGF-1R) and the chemokine G-protein coupled receptor, CXCR4 have been shown to play...

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Bibliographic Details
Main Authors: Niu Meizhi, Klingler-Hoffmann Manuela, Brazzatti Julie A, Forbes Briony, Akekawatchai Chareeporn, Hoffmann Peter, McColl Shaun R
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Proteome Science
Subjects:
Receptor transactivation
Cell migration
IGF-I
CXCR4
PI3Kγ
eEF2
2D-DIGE
Online Access:http://www.proteomesci.com/content/11/1/4

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