Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats

Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats

Intense physical activity and dieting are core symptoms of anorexia nervosa (AN). Their combination evolves into compulsivity, leading the patient into an out-of-control spiral. AN patients exhibit an altered activation of nucleus accumbens (NAc), revealing a dysfunctional mesocorticolimbic reward c...

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Bibliographic Details
Main Authors: Francesca Mottarlini, Giorgia Bottan, Benedetta Tarenzi, Alessandra Colciago, Fabio Fumagalli, Lucia Caffino
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Nutrients
Subjects:
nucleus accumbens
reward circuit
glutamatergic receptors
activity-based anorexia
adolescence
female rats
Online Access:https://www.mdpi.com/2072-6643/12/12/3661

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