Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study
Abstract Background Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without spinal implants is not well documented....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-08977-y |
| _version_ | 1797355930475560960 |
|---|---|
| author | Amélie Lombès Marie-Paule Fernandez-Gerlinger Marc Khalifé Najiby Kassis-Chikhani Amira Jomli Jean-Luc Mainardi David Lebeaux Marie Dubert |
| author_facet | Amélie Lombès Marie-Paule Fernandez-Gerlinger Marc Khalifé Najiby Kassis-Chikhani Amira Jomli Jean-Luc Mainardi David Lebeaux Marie Dubert |
| author_sort | Amélie Lombès |
| collection | DOAJ |
| description | Abstract Background Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without spinal implants is not well documented. Methods This single center retrospective 7-year observational study described and compared the outcome (treatment failure or mortality rate one year after diagnosis) of 20 patients with staphylococcal-implant-free pSSI treated with single or combination antibiotics. Results Median duration of treatment was 40 days (IQR 38–42), with 6 days (IQR 5–7) on intravenous antibiotics and 34 days (IQR 30–36) on oral therapy. Four patients (20%) underwent new surgical debridement, all due to surgical failure, and 1 patient died within the first year without significant differences between both treatment group. Conclusion This study raises the possibility of single antibiotic therapy for patients with implant-free post-surgical spinal infections due to Staphylococcus spp. |
| first_indexed | 2024-03-08T14:19:16Z |
| format | Article |
| id | doaj.art-882f62be5fb345cc80f9991ebea5b613 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T14:19:16Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-882f62be5fb345cc80f9991ebea5b6132024-01-14T12:13:16ZengBMCBMC Infectious Diseases1471-23342024-01-012411510.1186/s12879-024-08977-yEfficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational studyAmélie Lombès0Marie-Paule Fernandez-Gerlinger1Marc Khalifé2Najiby Kassis-Chikhani3Amira Jomli4Jean-Luc Mainardi5David Lebeaux6Marie Dubert7Mobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreOrthopedic surgery unit, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreInfection control unit, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreMicrobiology laboratory, AP-HP, Hôpital Européen Georges Pompidou, APHP- CentreMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreMobile infectious disease unit, Service de Microbiologie, AP-HP, Hôpital Européen Georges Pompidou, APHP-CentreAbstract Background Post-surgical spinal infections (pSSIs) are a serious complication of spinal surgeries, with Staphylococcus spp. being one of the most prominent bacteria identified. Optimal antimicrobial therapy for staphylococcal spinal infections without spinal implants is not well documented. Methods This single center retrospective 7-year observational study described and compared the outcome (treatment failure or mortality rate one year after diagnosis) of 20 patients with staphylococcal-implant-free pSSI treated with single or combination antibiotics. Results Median duration of treatment was 40 days (IQR 38–42), with 6 days (IQR 5–7) on intravenous antibiotics and 34 days (IQR 30–36) on oral therapy. Four patients (20%) underwent new surgical debridement, all due to surgical failure, and 1 patient died within the first year without significant differences between both treatment group. Conclusion This study raises the possibility of single antibiotic therapy for patients with implant-free post-surgical spinal infections due to Staphylococcus spp.https://doi.org/10.1186/s12879-024-08977-yStaphylococcusSpinalSurgical site infections (SSIs)Implant-freeSingle antibioticCombination antibiotic |
| spellingShingle | Amélie Lombès Marie-Paule Fernandez-Gerlinger Marc Khalifé Najiby Kassis-Chikhani Amira Jomli Jean-Luc Mainardi David Lebeaux Marie Dubert Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study BMC Infectious Diseases Staphylococcus Spinal Surgical site infections (SSIs) Implant-free Single antibiotic Combination antibiotic |
| title | Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study |
| title_full | Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study |
| title_fullStr | Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study |
| title_full_unstemmed | Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study |
| title_short | Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study |
| title_sort | efficacy of single antibiotic therapy versus antibiotic combination in implant free staphylococcal post surgical spinal infections a retrospective observational study |
| topic | Staphylococcus Spinal Surgical site infections (SSIs) Implant-free Single antibiotic Combination antibiotic |
| url | https://doi.org/10.1186/s12879-024-08977-y |
| work_keys_str_mv | AT amelielombes efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT mariepaulefernandezgerlinger efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT marckhalife efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT najibykassischikhani efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT amirajomli efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT jeanlucmainardi efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT davidlebeaux efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy AT mariedubert efficacyofsingleantibiotictherapyversusantibioticcombinationinimplantfreestaphylococcalpostsurgicalspinalinfectionsaretrospectiveobservationalstudy |