| Summary: | Background: Thymus and bone marrows are vital and primary organs of the lymphoid system and important targets for toxins and chemical agents. Objective: The aim was to study the role of clove oil on Cadmium-induced changes in TNFα and lymphatic tissues of adult Wistar rats. Methodology: Twenty-five rats were assigned into five groups of five rats each. Group 1 (Control) was allowed food and water only; group 2 was given 20 mg/kg of Cadmium chloride (CdCl2); group 3 received 20 mg/kg of CdCl2 with 10 mg/kg of Clove oil (CLO), group 4 received 20 mg/kg of CdCl with 20 mg/kg of CLO while group 5 received 20 mg/kg of CdCl and 20 mg/kg of DMSO. After the experiment, blood, bone marrow, and the thymus were harvested, processed, and analyzed. Results: There was a significant decrease in PCV, MCV, and MCH in group 2 compared to the control (p≤0.05). PCV, MCV, and MCH significantly increased in groups 3 and 4. The result of TNFα significantly increased in treated groups 3, 4, and 5 compared to group 2 (p≤0.05). The results showed normal architectural features of the bone marrow and thymus in control, while group 2 showed several structural distortions with many improvements in groups 3, 4, and 5. Conclusion: The study showed that clove oil ameliorated the toxicity associated with CdCl2 by normalizing hematological and immunological parameters.
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