Crohn’s Disease-Associated Adherent-Invasive Escherichia coli Manipulate Host Autophagy by Impairing SUMOylation

Crohn’s Disease-Associated Adherent-Invasive Escherichia coli Manipulate Host Autophagy by Impairing SUMOylation

The intestinal mucosa of Crohn’s disease (CD) patients is abnormally colonized with adherent-invasive Escherichia coli (AIEC) that are able to adhere to and to invade intestinal epithelial cells (IECs), to survive in macrophages, and to induce a pro-inflammatory response. AIEC persist in the intesti...

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Bibliographic Details
Main Authors: Guillaume Dalmasso, Hang T.T. Nguyen, Tiphanie Faïs, Sébastien Massier, Nicolas Barnich, Julien Delmas, Richard Bonnet
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
Crohn’s disease
AIEC
post-translational modifications
SUMO
autophagy
Online Access:http://www.mdpi.com/2073-4409/8/1/35

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