Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study
<h4>Background</h4> COVID-19 is a global public health problem causing high mortality worldwide. This study aimed to assess time to death and predictors of mortality among patients hospitalized for COVID-19 in the Arsi zone treatment center. <h4>Method</h4> We performed a ret...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084518/?tool=EBI |
| _version_ | 1818005619332874240 |
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| author | Abdene Weya Kaso Gebi Agero Zewdu Hurissa Taha Kaso Helen Ali Ewune Habtamu Endashaw Hareru Alemayehu Hailu |
| author_facet | Abdene Weya Kaso Gebi Agero Zewdu Hurissa Taha Kaso Helen Ali Ewune Habtamu Endashaw Hareru Alemayehu Hailu |
| author_sort | Abdene Weya Kaso |
| collection | DOAJ |
| description | <h4>Background</h4> COVID-19 is a global public health problem causing high mortality worldwide. This study aimed to assess time to death and predictors of mortality among patients hospitalized for COVID-19 in the Arsi zone treatment center. <h4>Method</h4> We performed a retrospective observational cohort study using medical records of laboratory-confirmed COVID-19 cases hospitalized at Bokoji Hospital COVID-19 treatment center from 1st July 2020 to 5th March 2021. We extracted data on the patients’ sociodemographic and clinical characteristics from medical records of hospitalized patients retrospectively. We carried out Kaplan Meier and Cox regression analysis to estimate survival probability and investigate predictors of COVID-19 death 5% level of significance. The Adjusted Hazard Ratio (aHR) with 95% Confidence Interval (CI) was estimated and interpreted for predictors of time to death in the final cox model. <h4>Result</h4> A total of 422 COVID-19 patients treated were analyzed, of these more than one tenth (11.14%) deaths, with a mortality rate of 6.35 cases per 1000 person-days. The majority (87.2%) of deaths occurred within the first 14 days of admission, with a median time-to-death of nine (IQR: 8–12) days. We found patients that age between 31 and 45 years (aHR = 2.55; 95% CI: (1.03, 6.34), older than 46 years (aHR = 2.59 (1.27, 5.30), chronic obstructive pulmonary disease (aHR = 4.60, 95%CI: (2.37, 8.91), Chronic kidney disease (aHR = 5.58, 95%CI: (1.70, 18.37), HIV/AIDS (aHR = 3.66, 95%CI: (1.20, 11.10), admission to the Intensive care unit(aHR = 7.44, 95%CI: (1.82, 30.42), and being on intranasal oxygen care (aHR = 6.27, 95%CI: (2.75, 4.30) were independent risk factors increasing risk of death from COVID-19 disease than their counterparts. <h4>Conclusion</h4> The risk of dying due to COVID-19 disease was higher among patients with HIV/AIDS, chronic obstructive pulmonary disease, and chronic kidney diseases. We also found that older people, those admitted to ICU, and patients who received intranasal oxygen care had a higher risk of dying due to COVID-19 disease. Therefore, close monitoring hospitalized patients that are old aged and those with comorbidities after hospitalization is crucial within the first ten days of admission. |
| first_indexed | 2024-04-14T04:47:22Z |
| format | Article |
| id | doaj.art-88323c6755134d6481baefe5111b4468 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T04:47:22Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-88323c6755134d6481baefe5111b44682022-12-22T02:11:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01175Survival analysis of COVID-19 patients in Ethiopia: A hospital-based studyAbdene Weya KasoGebi AgeroZewdu HurissaTaha KasoHelen Ali EwuneHabtamu Endashaw HareruAlemayehu Hailu<h4>Background</h4> COVID-19 is a global public health problem causing high mortality worldwide. This study aimed to assess time to death and predictors of mortality among patients hospitalized for COVID-19 in the Arsi zone treatment center. <h4>Method</h4> We performed a retrospective observational cohort study using medical records of laboratory-confirmed COVID-19 cases hospitalized at Bokoji Hospital COVID-19 treatment center from 1st July 2020 to 5th March 2021. We extracted data on the patients’ sociodemographic and clinical characteristics from medical records of hospitalized patients retrospectively. We carried out Kaplan Meier and Cox regression analysis to estimate survival probability and investigate predictors of COVID-19 death 5% level of significance. The Adjusted Hazard Ratio (aHR) with 95% Confidence Interval (CI) was estimated and interpreted for predictors of time to death in the final cox model. <h4>Result</h4> A total of 422 COVID-19 patients treated were analyzed, of these more than one tenth (11.14%) deaths, with a mortality rate of 6.35 cases per 1000 person-days. The majority (87.2%) of deaths occurred within the first 14 days of admission, with a median time-to-death of nine (IQR: 8–12) days. We found patients that age between 31 and 45 years (aHR = 2.55; 95% CI: (1.03, 6.34), older than 46 years (aHR = 2.59 (1.27, 5.30), chronic obstructive pulmonary disease (aHR = 4.60, 95%CI: (2.37, 8.91), Chronic kidney disease (aHR = 5.58, 95%CI: (1.70, 18.37), HIV/AIDS (aHR = 3.66, 95%CI: (1.20, 11.10), admission to the Intensive care unit(aHR = 7.44, 95%CI: (1.82, 30.42), and being on intranasal oxygen care (aHR = 6.27, 95%CI: (2.75, 4.30) were independent risk factors increasing risk of death from COVID-19 disease than their counterparts. <h4>Conclusion</h4> The risk of dying due to COVID-19 disease was higher among patients with HIV/AIDS, chronic obstructive pulmonary disease, and chronic kidney diseases. We also found that older people, those admitted to ICU, and patients who received intranasal oxygen care had a higher risk of dying due to COVID-19 disease. Therefore, close monitoring hospitalized patients that are old aged and those with comorbidities after hospitalization is crucial within the first ten days of admission.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084518/?tool=EBI |
| spellingShingle | Abdene Weya Kaso Gebi Agero Zewdu Hurissa Taha Kaso Helen Ali Ewune Habtamu Endashaw Hareru Alemayehu Hailu Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study PLoS ONE |
| title | Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study |
| title_full | Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study |
| title_fullStr | Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study |
| title_full_unstemmed | Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study |
| title_short | Survival analysis of COVID-19 patients in Ethiopia: A hospital-based study |
| title_sort | survival analysis of covid 19 patients in ethiopia a hospital based study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084518/?tool=EBI |
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