The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation
Despite improvements in short-term and long-term outcomes of liver transplant patients, the discrepancy between the number of available livers and transplant candidates continues to increase. The use of expanded criteria donors is one strategy that can be used to address donor shortages. In recent y...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Livers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4389/3/4/46 |
| _version_ | 1797380268022038528 |
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| author | Dima Malkawi Kush Savsani Anjelica Alfonso Seung Duk Lee Nicholas James Devanand Sarkar Daisuke Imai Aamir Khan Amit Sharma Vinay Kumaran David Bruno Adrian Cotterell Marlon F. Levy |
| author_facet | Dima Malkawi Kush Savsani Anjelica Alfonso Seung Duk Lee Nicholas James Devanand Sarkar Daisuke Imai Aamir Khan Amit Sharma Vinay Kumaran David Bruno Adrian Cotterell Marlon F. Levy |
| author_sort | Dima Malkawi |
| collection | DOAJ |
| description | Despite improvements in short-term and long-term outcomes of liver transplant patients, the discrepancy between the number of available livers and transplant candidates continues to increase. The use of expanded criteria donors is one strategy that can be used to address donor shortages. In recent years, preservation strategies such as normothermic machine perfusion (NMP) have been explored to improve the preservation of organs and test their viability before transplantation. We reviewed the recent literature and trials assessing the use of NMP in the setting of liver transplantation. Multiple feasibility trials have demonstrated the clinical prospect of NMP and proved its numerous advantages compared to conventional static cold storage. These advantages include preservation and viability assessment of high-risk donor allografts and grafts that would have otherwise been discarded. This review aims to address the topic of liver NMP in the setting of current and future applications in the setting of extended criteria donor grafts. |
| first_indexed | 2024-03-08T20:34:58Z |
| format | Article |
| id | doaj.art-8832e8c9f6de480fb04bc502581f7c9a |
| institution | Directory Open Access Journal |
| issn | 2673-4389 |
| language | English |
| last_indexed | 2024-03-08T20:34:58Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Livers |
| spelling | doaj.art-8832e8c9f6de480fb04bc502581f7c9a2023-12-22T14:21:32ZengMDPI AGLivers2673-43892023-12-013470972610.3390/livers3040046The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and PreservationDima Malkawi0Kush Savsani1Anjelica Alfonso2Seung Duk Lee3Nicholas James4Devanand Sarkar5Daisuke Imai6Aamir Khan7Amit Sharma8Vinay Kumaran9David Bruno10Adrian Cotterell11Marlon F. Levy12School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USASchool of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADivision of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298, USADespite improvements in short-term and long-term outcomes of liver transplant patients, the discrepancy between the number of available livers and transplant candidates continues to increase. The use of expanded criteria donors is one strategy that can be used to address donor shortages. In recent years, preservation strategies such as normothermic machine perfusion (NMP) have been explored to improve the preservation of organs and test their viability before transplantation. We reviewed the recent literature and trials assessing the use of NMP in the setting of liver transplantation. Multiple feasibility trials have demonstrated the clinical prospect of NMP and proved its numerous advantages compared to conventional static cold storage. These advantages include preservation and viability assessment of high-risk donor allografts and grafts that would have otherwise been discarded. This review aims to address the topic of liver NMP in the setting of current and future applications in the setting of extended criteria donor grafts.https://www.mdpi.com/2673-4389/3/4/46liver transplantnormothermicmachine perfusionextended criteria donor |
| spellingShingle | Dima Malkawi Kush Savsani Anjelica Alfonso Seung Duk Lee Nicholas James Devanand Sarkar Daisuke Imai Aamir Khan Amit Sharma Vinay Kumaran David Bruno Adrian Cotterell Marlon F. Levy The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation Livers liver transplant normothermic machine perfusion extended criteria donor |
| title | The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation |
| title_full | The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation |
| title_fullStr | The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation |
| title_full_unstemmed | The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation |
| title_short | The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation |
| title_sort | role of normothermic machine perfusion in extended criteria donor grafts a new direction in liver graft assessment and preservation |
| topic | liver transplant normothermic machine perfusion extended criteria donor |
| url | https://www.mdpi.com/2673-4389/3/4/46 |
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