Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine
Hepatitis B virus (HBV) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world. The WHO strategy for effective control of HBV infection and its complications is mass vaccination of neonates and children within the f...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2015-10-01
|
| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/563 |
| _version_ | 1818273639621984256 |
|---|---|
| author | Abdollah Jafarzadeh Masoome Bagheri-Jamebozorgi Maryam Nemati Forough Golsaz-Shirazi Fazel Shokri |
| author_facet | Abdollah Jafarzadeh Masoome Bagheri-Jamebozorgi Maryam Nemati Forough Golsaz-Shirazi Fazel Shokri |
| author_sort | Abdollah Jafarzadeh |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world. The WHO strategy for effective control of HBV infection and its complications is mass vaccination of neonates and children within the framework of Expanded Programme on Immunization (EPI). Vaccination with hepatitis B surface antigen (HBsAg) induces protective antibody response (anti-HBs ≥ 10 IU/L) in 90-99% of vaccinees.The lack of response to HBsAg has been attributed to a variety of immunological mechanisms, including defect in antigen presentation, defect in HBsAg-specific T and/or B cell repertoires, T-cell suppression, increase in the regulatory T cell count, lack of necessary help of T-cells for production of anti-HBs by B cells, defect in Th1 and/or Th2 cytokine production and selective killing of HBsAg-specific B-cells by human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes. The HLA complex plays an important role in many of these immunological processes.A variety of HLA class I, II, and III alleles and antigens have been reported to beassociated with antibody response to HBsAg vaccination in different ethnic populations. Moreover, some HLA haplotypes were also associated with responsiveness to HBsAg.In this review the association of the HLA specificities with antibody response to hepatitis B (HB) vaccine is discussed. |
| first_indexed | 2024-12-12T22:01:10Z |
| format | Article |
| id | doaj.art-8833584912464971a37c60c3a74d3789 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-12T22:01:10Z |
| publishDate | 2015-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-8833584912464971a37c60c3a74d37892022-12-22T00:10:31ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492015-10-01143527Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B VaccineAbdollah Jafarzadeh0Masoome Bagheri-Jamebozorgi1Maryam Nemati2Forough Golsaz-Shirazi3Fazel Shokri4Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, IranHepatitis B virus (HBV) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world. The WHO strategy for effective control of HBV infection and its complications is mass vaccination of neonates and children within the framework of Expanded Programme on Immunization (EPI). Vaccination with hepatitis B surface antigen (HBsAg) induces protective antibody response (anti-HBs ≥ 10 IU/L) in 90-99% of vaccinees.The lack of response to HBsAg has been attributed to a variety of immunological mechanisms, including defect in antigen presentation, defect in HBsAg-specific T and/or B cell repertoires, T-cell suppression, increase in the regulatory T cell count, lack of necessary help of T-cells for production of anti-HBs by B cells, defect in Th1 and/or Th2 cytokine production and selective killing of HBsAg-specific B-cells by human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes. The HLA complex plays an important role in many of these immunological processes.A variety of HLA class I, II, and III alleles and antigens have been reported to beassociated with antibody response to HBsAg vaccination in different ethnic populations. Moreover, some HLA haplotypes were also associated with responsiveness to HBsAg.In this review the association of the HLA specificities with antibody response to hepatitis B (HB) vaccine is discussed.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/563Hepatitis B vaccineHepatitis B antibodiesHuman leukocyte antigen |
| spellingShingle | Abdollah Jafarzadeh Masoome Bagheri-Jamebozorgi Maryam Nemati Forough Golsaz-Shirazi Fazel Shokri Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine Iranian Journal of Allergy, Asthma and Immunology Hepatitis B vaccine Hepatitis B antibodies Human leukocyte antigen |
| title | Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine |
| title_full | Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine |
| title_fullStr | Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine |
| title_full_unstemmed | Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine |
| title_short | Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine |
| title_sort | human leukocyte antigens influence the antibody response to hepatitis b vaccine |
| topic | Hepatitis B vaccine Hepatitis B antibodies Human leukocyte antigen |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/563 |
| work_keys_str_mv | AT abdollahjafarzadeh humanleukocyteantigensinfluencetheantibodyresponsetohepatitisbvaccine AT masoomebagherijamebozorgi humanleukocyteantigensinfluencetheantibodyresponsetohepatitisbvaccine AT maryamnemati humanleukocyteantigensinfluencetheantibodyresponsetohepatitisbvaccine AT foroughgolsazshirazi humanleukocyteantigensinfluencetheantibodyresponsetohepatitisbvaccine AT fazelshokri humanleukocyteantigensinfluencetheantibodyresponsetohepatitisbvaccine |