SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn’s Disease and Peripheral T Cell Reduction
In our previous study, we observed a severe reduction in the Src homology 2-containing-inositol-phosphatase-1 (SHIP1) protein in a subpopulation of subjects from a small adult Crohn’s Disease (CD) cohort. This pilot study had been undertaken since we had previously demonstrated that engineered defic...
Main Authors: | Sandra Fernandes, Neetu Srivastava, Raki Sudan, Frank A. Middleton, Amandeep K. Shergill, James C. Ryan, William G. Kerr |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-05-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01100/full |
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