3236 Identification of exhaustive markers in cytotoxic T-cells to guide immune modulation in hepatocellular carcinoma ex vivo

3236 Identification of exhaustive markers in cytotoxic T-cells to guide immune modulation in hepatocellular carcinoma ex vivo

OBJECTIVES/SPECIFIC AIMS: Objective: apply checkpoint inhibitors that are specific to the exhaustive markers expressed on tumor CD8+ T-cells ex vivo in order to improve cytokine release and cytotoxic function in comparison to two control groups: (1.) T-cells that receive no antibodies; (2.) T-cells...

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Bibliographic Details
Main Authors:	Lauren Norell Krumeich, Tatiana Akimova, Jason Stadanlick, Abhishek Rao, Neil Sullivan, Seth Concors, Paul Hernandez, David Aufhauser, Evgeniy Eruslanov, Wayne Hancock, Matthew Levine
Format:	Article
Language:	English
Published:	Cambridge University Press 2019-03-01
Series:	Journal of Clinical and Translational Science
Online Access:	https://www.cambridge.org/core/product/identifier/S2059866119000335/type/journal_article

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