The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa
Objectives: The aim of this study was to assess the effect of vitamins B12, B6 and folate supplementation at >100% Recommended Dietary Allowances (RDA) for six months on serum homocysteine (Hcy) levels of an elderly urbanised black South African community. Design: An experimental, non-equivalent...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-11-01
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| Series: | The South African Journal of Clinical Nutrition |
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| Online Access: | http://dx.doi.org/10.1080/16070658.2021.2003148 |
| _version_ | 1827811395054338048 |
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| author | CJ Grobler WH Oldewage-Theron JM Chalwe |
| author_facet | CJ Grobler WH Oldewage-Theron JM Chalwe |
| author_sort | CJ Grobler |
| collection | DOAJ |
| description | Objectives: The aim of this study was to assess the effect of vitamins B12, B6 and folate supplementation at >100% Recommended Dietary Allowances (RDA) for six months on serum homocysteine (Hcy) levels of an elderly urbanised black South African community. Design: An experimental, non-equivalent control group intervention study design was used in a 104 purposively selected sample. Two groups were compared: hyperhomocysteinaemic (hyperHcy) (n = 61) and normo-homocysteinaemic (normoHcy) (n = 43). Setting: Elders attending a day-care centre in Sharpeville, Gauteng, South Africa. Subjects: All subjects were equivalent in age (> 60 years), race (black) and unemployed/pensioner. Outcome measures: The following parameters were determined at baseline and after the six-month supplementation: serum Hcy, vitamins B6, B12 and folate levels, red cell count, mean cell volume, haemoglobin, haematocrit and the nutritional intake of vitamin B6, B12 and folate. Results: A very high incidence (66.36%) of hyperhomocysteinaemia was present in the sample. The mean ± standard deviation (SD) serum Hcy level in hyperhomocysteinaemic individuals decreased statistically significantly from 25.00 ± 8.00 umol/l to 18.80 ± 12.00 umol/l after the intervention. The number of respondents with an increased Hcy level decreased from 100% (baseline) to 67% after the intervention. Conclusions: It is concluded that supplementation of vitamins B6, B12 and folate is an effective Hcy-lowering approach to reduce hyperhomocysteinaemia in an elderly population, and thereby reduce their risk of cardiovascular disease (CVD). Summary The supplementation had a beneficial effect on the respondents’ serum vitamin B6 as well as their haemopoiesis (decreased macrocytosis). |
| first_indexed | 2024-03-11T23:04:32Z |
| format | Article |
| id | doaj.art-8837d6c1e7e94988b61c19109ed05d06 |
| institution | Directory Open Access Journal |
| issn | 1607-0658 2221-1268 |
| language | English |
| last_indexed | 2024-03-11T23:04:32Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The South African Journal of Clinical Nutrition |
| spelling | doaj.art-8837d6c1e7e94988b61c19109ed05d062023-09-21T13:38:27ZengTaylor & Francis GroupThe South African Journal of Clinical Nutrition1607-06582221-12682022-11-0135416216710.1080/16070658.2021.20031482003148The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South AfricaCJ Grobler0WH Oldewage-Theron1JM Chalwe2Vaal University of TechnologyTexas Tech University (TTU)Vaal University of TechnologyObjectives: The aim of this study was to assess the effect of vitamins B12, B6 and folate supplementation at >100% Recommended Dietary Allowances (RDA) for six months on serum homocysteine (Hcy) levels of an elderly urbanised black South African community. Design: An experimental, non-equivalent control group intervention study design was used in a 104 purposively selected sample. Two groups were compared: hyperhomocysteinaemic (hyperHcy) (n = 61) and normo-homocysteinaemic (normoHcy) (n = 43). Setting: Elders attending a day-care centre in Sharpeville, Gauteng, South Africa. Subjects: All subjects were equivalent in age (> 60 years), race (black) and unemployed/pensioner. Outcome measures: The following parameters were determined at baseline and after the six-month supplementation: serum Hcy, vitamins B6, B12 and folate levels, red cell count, mean cell volume, haemoglobin, haematocrit and the nutritional intake of vitamin B6, B12 and folate. Results: A very high incidence (66.36%) of hyperhomocysteinaemia was present in the sample. The mean ± standard deviation (SD) serum Hcy level in hyperhomocysteinaemic individuals decreased statistically significantly from 25.00 ± 8.00 umol/l to 18.80 ± 12.00 umol/l after the intervention. The number of respondents with an increased Hcy level decreased from 100% (baseline) to 67% after the intervention. Conclusions: It is concluded that supplementation of vitamins B6, B12 and folate is an effective Hcy-lowering approach to reduce hyperhomocysteinaemia in an elderly population, and thereby reduce their risk of cardiovascular disease (CVD). Summary The supplementation had a beneficial effect on the respondents’ serum vitamin B6 as well as their haemopoiesis (decreased macrocytosis).http://dx.doi.org/10.1080/16070658.2021.2003148cardiovascular riskfolatehcysupplementationvitamin b6vitamin b12 |
| spellingShingle | CJ Grobler WH Oldewage-Theron JM Chalwe The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa The South African Journal of Clinical Nutrition cardiovascular risk folate hcy supplementation vitamin b6 vitamin b12 |
| title | The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa |
| title_full | The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa |
| title_fullStr | The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa |
| title_full_unstemmed | The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa |
| title_short | The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa |
| title_sort | effect of vitamins b12 b6 and folate supplementation on homocysteine metabolism in a low income urbanised black elderly community in south africa |
| topic | cardiovascular risk folate hcy supplementation vitamin b6 vitamin b12 |
| url | http://dx.doi.org/10.1080/16070658.2021.2003148 |
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