Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis
Key Clinical Message When faced with a slowly enlarging firm mass in the parotid gland accompanied by a histological picture of unusual sclerosis with abundant Langerhans cells and eosinophilic infiltrates, sclerosing mucoepidermoid carcinoma with eosinophilia should be considered as one of the diff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.7488 |
| _version_ | 1797791748268752896 |
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| author | Florence Man Fung Cheung Chit Chow Jimmy Yu Wai Chan |
| author_facet | Florence Man Fung Cheung Chit Chow Jimmy Yu Wai Chan |
| author_sort | Florence Man Fung Cheung |
| collection | DOAJ |
| description | Key Clinical Message When faced with a slowly enlarging firm mass in the parotid gland accompanied by a histological picture of unusual sclerosis with abundant Langerhans cells and eosinophilic infiltrates, sclerosing mucoepidermoid carcinoma with eosinophilia should be considered as one of the differential diagnoses. Further studies are warranted for accurate diagnosis and appropriate treatment. Abstract Sclerosing mucoepidermoid carcinoma of the salivary gland with eosinophilia is a rare tumor mostly negative for the MAML2 rearrangement commonly seen in salivary mucoepidermoid carcinoma. It was not listed as an entity in the 2022 WHO Classification of Head and Neck Tumors. We presented one case initially diagnosed as Langerhans cell histiocytosis and recurred as a frankly invasive carcinoma. Molecular studies showed CSF1 gene derangement and provided new understanding concerning the Langerhans cell and eosinophilic reaction. Further molecular studies on this entity would throw light on its oncogenesis and refine its nomenclature. |
| first_indexed | 2024-03-13T02:23:09Z |
| format | Article |
| id | doaj.art-8838bd36b4d147ca96c56bdbc7c7fd14 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-13T02:23:09Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-8838bd36b4d147ca96c56bdbc7c7fd142023-06-30T07:34:07ZengWileyClinical Case Reports2050-09042023-06-01116n/an/a10.1002/ccr3.7488Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosisFlorence Man Fung Cheung0Chit Chow1Jimmy Yu Wai Chan2Clinical Laboratory Gleneagles Hospital Hong Kong Hong Kong Hong KongDepartment of Anatomical and Cellular Pathology Chinese University of Hong Kong Hong Kong Hong KongChief of Division of Head and Neck Surgery and Division of Plastic and Reconstructive Surgery, School of Medicine University of Hong Kong Hong Kong Hong KongKey Clinical Message When faced with a slowly enlarging firm mass in the parotid gland accompanied by a histological picture of unusual sclerosis with abundant Langerhans cells and eosinophilic infiltrates, sclerosing mucoepidermoid carcinoma with eosinophilia should be considered as one of the differential diagnoses. Further studies are warranted for accurate diagnosis and appropriate treatment. Abstract Sclerosing mucoepidermoid carcinoma of the salivary gland with eosinophilia is a rare tumor mostly negative for the MAML2 rearrangement commonly seen in salivary mucoepidermoid carcinoma. It was not listed as an entity in the 2022 WHO Classification of Head and Neck Tumors. We presented one case initially diagnosed as Langerhans cell histiocytosis and recurred as a frankly invasive carcinoma. Molecular studies showed CSF1 gene derangement and provided new understanding concerning the Langerhans cell and eosinophilic reaction. Further molecular studies on this entity would throw light on its oncogenesis and refine its nomenclature.https://doi.org/10.1002/ccr3.7488CSF1eosinophiliaLangerhans cellsSclerosing mucoepidermoid carcinoma |
| spellingShingle | Florence Man Fung Cheung Chit Chow Jimmy Yu Wai Chan Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis Clinical Case Reports CSF1 eosinophilia Langerhans cells Sclerosing mucoepidermoid carcinoma |
| title | Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis |
| title_full | Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis |
| title_fullStr | Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis |
| title_full_unstemmed | Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis |
| title_short | Detection of CSF1 gene derangement in ‘sclerosing mucoepidermoid carcinoma with eosinophilia’ of the parotid gland masquerading as Langerhans cell histiocytosis |
| title_sort | detection of csf1 gene derangement in sclerosing mucoepidermoid carcinoma with eosinophilia of the parotid gland masquerading as langerhans cell histiocytosis |
| topic | CSF1 eosinophilia Langerhans cells Sclerosing mucoepidermoid carcinoma |
| url | https://doi.org/10.1002/ccr3.7488 |
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