Problems of the differential diagnosis of diabetes mellitus in children
Along with the increasing prevalence of type 1 diabetes among children and adolescents, there is a growth of rare variants of the disease — type 2 diabetes and monogenic forms of diabetes.Objective. To study the characteristics of clinical course of diabetes mellitus in patients under 18 years, depe...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2020-11-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1255 |
| _version_ | 1797875181448855552 |
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| author | M. R. Shaidullina A. Kh. Gumerova R. A. Sapralieva |
| author_facet | M. R. Shaidullina A. Kh. Gumerova R. A. Sapralieva |
| author_sort | M. R. Shaidullina |
| collection | DOAJ |
| description | Along with the increasing prevalence of type 1 diabetes among children and adolescents, there is a growth of rare variants of the disease — type 2 diabetes and monogenic forms of diabetes.Objective. To study the characteristics of clinical course of diabetes mellitus in patients under 18 years, depending on the type of disease. Children characteristics and research methods. The researchers compared age, gender, and clinical and laboratory characteristics in the debut of the pathology in 43 patients with an atypical manifestation of type 1 diabetes mellitus.Results. Despite the non-standard clinical manifestations of the disease, 62.8% of the patients in this cohort account for children with type 1 diabetes mellitus, 23.3% — for patients with MODY diabetes (23.3%), and 13.9% — for type 2 diabetes mellitus. There were no clinical and laboratory markers (due to insufficient number of patients), such as: burdened heredity, patient weight, level of residual secretion of insulin, glycemia, glycated hemoglobin at the moment of manifestation, which could be used as a guideline for the differential diagnosis. This fact justifies the usage of the entire range of laboratory and molecular genetic studies to verily the diagnosis. |
| first_indexed | 2024-04-10T01:42:28Z |
| format | Article |
| id | doaj.art-883a064888d94dd7837195f43168be36 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:42:28Z |
| publishDate | 2020-11-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-883a064888d94dd7837195f43168be362023-03-13T09:12:49ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282020-11-0165517618010.21508/1027-4065-2020-65-5-176-180955Problems of the differential diagnosis of diabetes mellitus in childrenM. R. Shaidullina0A. Kh. Gumerova1R. A. Sapralieva2ФГБОУ ВО Казанский государственный медицинский университет Минздрава России; ГАУЗ Детская республиканская клиническая больница Минздрава Республики ТатарстанГАУЗ Детская республиканская клиническая больница Минздрава Республики ТатарстанФГБОУ ВО Казанский государственный медицинский университет Минздрава РоссииAlong with the increasing prevalence of type 1 diabetes among children and adolescents, there is a growth of rare variants of the disease — type 2 diabetes and monogenic forms of diabetes.Objective. To study the characteristics of clinical course of diabetes mellitus in patients under 18 years, depending on the type of disease. Children characteristics and research methods. The researchers compared age, gender, and clinical and laboratory characteristics in the debut of the pathology in 43 patients with an atypical manifestation of type 1 diabetes mellitus.Results. Despite the non-standard clinical manifestations of the disease, 62.8% of the patients in this cohort account for children with type 1 diabetes mellitus, 23.3% — for patients with MODY diabetes (23.3%), and 13.9% — for type 2 diabetes mellitus. There were no clinical and laboratory markers (due to insufficient number of patients), such as: burdened heredity, patient weight, level of residual secretion of insulin, glycemia, glycated hemoglobin at the moment of manifestation, which could be used as a guideline for the differential diagnosis. This fact justifies the usage of the entire range of laboratory and molecular genetic studies to verily the diagnosis.https://www.ped-perinatology.ru/jour/article/view/1255детиcахарный диабет 1-го типаcахарный диабет 2-го типаmody2mody5манифестациядифференциальная диагностикаген gckген hnf1fi |
| spellingShingle | M. R. Shaidullina A. Kh. Gumerova R. A. Sapralieva Problems of the differential diagnosis of diabetes mellitus in children Rossijskij Vestnik Perinatologii i Pediatrii дети cахарный диабет 1-го типа cахарный диабет 2-го типа mody2 mody5 манифестация дифференциальная диагностика ген gck ген hnf1fi |
| title | Problems of the differential diagnosis of diabetes mellitus in children |
| title_full | Problems of the differential diagnosis of diabetes mellitus in children |
| title_fullStr | Problems of the differential diagnosis of diabetes mellitus in children |
| title_full_unstemmed | Problems of the differential diagnosis of diabetes mellitus in children |
| title_short | Problems of the differential diagnosis of diabetes mellitus in children |
| title_sort | problems of the differential diagnosis of diabetes mellitus in children |
| topic | дети cахарный диабет 1-го типа cахарный диабет 2-го типа mody2 mody5 манифестация дифференциальная диагностика ген gck ген hnf1fi |
| url | https://www.ped-perinatology.ru/jour/article/view/1255 |
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