Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding
Time-restricted feeding (TRF) is becoming a popular way of eating in physically active populations, despite a lack of research on metabolic and performance outcomes as they relate to the timing of food consumption in relation to the time of exercise. The purpose of this study was to determine if the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/5/1717 |
| _version_ | 1797533554862718976 |
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| author | Aaron Persinger Matthew Butawan Martina Faietti Ashley Pryke Kyley Rose Marie van der Merwe Richard J. Bloomer Melissa J. Puppa |
| author_facet | Aaron Persinger Matthew Butawan Martina Faietti Ashley Pryke Kyley Rose Marie van der Merwe Richard J. Bloomer Melissa J. Puppa |
| author_sort | Aaron Persinger |
| collection | DOAJ |
| description | Time-restricted feeding (TRF) is becoming a popular way of eating in physically active populations, despite a lack of research on metabolic and performance outcomes as they relate to the timing of food consumption in relation to the time of exercise. The purpose of this study was to determine if the timing of feeding/fasting after exercise training differently affects muscle metabolic flexibility and response to an acute bout of exercise. Male C57BL/6 mice were randomized to one of three groups for 8 weeks. The control had ad libitum access to food before and after exercise training. TRF-immediate had immediate access to food for 6 h following exercise training and the TRF-delayed group had access to food 5-h post exercise for 6 h. The timing of fasting did not impact performance in a run to fatigue despite TRF groups having lower hindlimb muscle mass. TRF-delayed had lower levels of muscle HSL mRNA expression and lower levels of PGC-1α expression but displayed no changes in electron transport chain enzymes. These results suggest that in young populations consuming a healthy diet and exercising, the timing of fasting may not substantially impact metabolic flexibility and running performance. |
| first_indexed | 2024-03-10T11:16:16Z |
| format | Article |
| id | doaj.art-883b673203d840f782c5d26275a326a3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T11:16:16Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-883b673203d840f782c5d26275a326a32023-11-21T20:23:12ZengMDPI AGNutrients2072-66432021-05-01135171710.3390/nu13051717Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted FeedingAaron Persinger0Matthew Butawan1Martina Faietti2Ashley Pryke3Kyley Rose4Marie van der Merwe5Richard J. Bloomer6Melissa J. Puppa7College of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USACollege of Health Sciences Memphis, University of Memphis, Memphis, TN 38152, USATime-restricted feeding (TRF) is becoming a popular way of eating in physically active populations, despite a lack of research on metabolic and performance outcomes as they relate to the timing of food consumption in relation to the time of exercise. The purpose of this study was to determine if the timing of feeding/fasting after exercise training differently affects muscle metabolic flexibility and response to an acute bout of exercise. Male C57BL/6 mice were randomized to one of three groups for 8 weeks. The control had ad libitum access to food before and after exercise training. TRF-immediate had immediate access to food for 6 h following exercise training and the TRF-delayed group had access to food 5-h post exercise for 6 h. The timing of fasting did not impact performance in a run to fatigue despite TRF groups having lower hindlimb muscle mass. TRF-delayed had lower levels of muscle HSL mRNA expression and lower levels of PGC-1α expression but displayed no changes in electron transport chain enzymes. These results suggest that in young populations consuming a healthy diet and exercising, the timing of fasting may not substantially impact metabolic flexibility and running performance.https://www.mdpi.com/2072-6643/13/5/1717time-restricted feedingaerobic trainingskeletal muscle metabolism |
| spellingShingle | Aaron Persinger Matthew Butawan Martina Faietti Ashley Pryke Kyley Rose Marie van der Merwe Richard J. Bloomer Melissa J. Puppa Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding Nutrients time-restricted feeding aerobic training skeletal muscle metabolism |
| title | Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding |
| title_full | Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding |
| title_fullStr | Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding |
| title_full_unstemmed | Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding |
| title_short | Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding |
| title_sort | effects of feeding time on markers of muscle metabolic flexibility following acute aerobic exercise in trained mice undergoing time restricted feeding |
| topic | time-restricted feeding aerobic training skeletal muscle metabolism |
| url | https://www.mdpi.com/2072-6643/13/5/1717 |
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