Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities
This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliogr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/10/933 |
| _version_ | 1797552226270445568 |
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| author | Verônica da Silva Oliveira Amanda Silva de Almeida Ingrid da Silva Albuquerque Fernanda Ílary Costa Duarte Bárbara Cristina Silva Holanda Queiroz Attilio Converti Ádley Antonini Neves de Lima |
| author_facet | Verônica da Silva Oliveira Amanda Silva de Almeida Ingrid da Silva Albuquerque Fernanda Ílary Costa Duarte Bárbara Cristina Silva Holanda Queiroz Attilio Converti Ádley Antonini Neves de Lima |
| author_sort | Verônica da Silva Oliveira |
| collection | DOAJ |
| description | This review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications. |
| first_indexed | 2024-03-10T15:56:55Z |
| format | Article |
| id | doaj.art-883c78d2138746ae9a59d94a7dde3274 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T15:56:55Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-883c78d2138746ae9a59d94a7dde32742023-11-20T15:35:37ZengMDPI AGPharmaceutics1999-49232020-09-01121093310.3390/pharmaceutics12100933Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo ActivitiesVerônica da Silva Oliveira0Amanda Silva de Almeida1Ingrid da Silva Albuquerque2Fernanda Ílary Costa Duarte3Bárbara Cristina Silva Holanda Queiroz4Attilio Converti5Ádley Antonini Neves de Lima6Postgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, BrazilDepartment of Pharmacy, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, BrazilDepartment of Pharmacy, Universidade Federal do Rio Grande do Norte, Natal-RN 59012-570, BrazilPostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, BrazilPostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, BrazilDepartment of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, I-16145 Genoa, ItalyPostgraduate Program in Pharmaceutical Sciences, Health Sciences Center, Federal University of Rio Grande do Norte, Natal-RN 59012-570, BrazilThis review aims to provide an overview of studies that address the use, in therapeutic applications, of solid dispersions (SDs) with biological activities in vitro and/or in vivo mainly made up of polymeric matrices, as well as to evaluate the bioactive activity of their constituents. This bibliographic survey shows that the development of solid dispersions provides benefits in the physicochemical properties of bioactive compounds, which lead to an increase in their biological potential. However, despite the reports found on solid dispersions, there is still a need for biological assay-based studies, mainly in vivo, to assist in the investigation and to devise new applications. Therefore, studies based on such an approach are of great importance to enhance and extend the use of solid dispersions in the most diverse therapeutic applications.https://www.mdpi.com/1999-4923/12/10/933solid dispersionsdrug deliverybiological applications |
| spellingShingle | Verônica da Silva Oliveira Amanda Silva de Almeida Ingrid da Silva Albuquerque Fernanda Ílary Costa Duarte Bárbara Cristina Silva Holanda Queiroz Attilio Converti Ádley Antonini Neves de Lima Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities Pharmaceutics solid dispersions drug delivery biological applications |
| title | Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities |
| title_full | Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities |
| title_fullStr | Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities |
| title_full_unstemmed | Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities |
| title_short | Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities |
| title_sort | therapeutic applications of solid dispersions for drugs and new molecules in vitro and in vivo activities |
| topic | solid dispersions drug delivery biological applications |
| url | https://www.mdpi.com/1999-4923/12/10/933 |
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