Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center
Introduction: Gonadotropins are the main drugs for ovarian stimulation in assisted reproductive cycles. There are many different types of urine, purified or recombinant gonadotropins. This study was performed aimed to compare the clinical outcomes of two types of recombinant Cinal F gonadotropin Ira...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Mashhad University of Medical Sciences
2022-07-01
|
| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| Subjects: | |
| Online Access: | https://ijogi.mums.ac.ir/article_20793_40ef1c6cd9e76918887ed9fb5d6ca4f4.pdf |
| _version_ | 1797984622357774336 |
|---|---|
| author | Faizeh Mashhadi Malihe Mahmoudinia Tahere Sadeghi Nafiseh Jahanpak Nayereh Khadem |
| author_facet | Faizeh Mashhadi Malihe Mahmoudinia Tahere Sadeghi Nafiseh Jahanpak Nayereh Khadem |
| author_sort | Faizeh Mashhadi |
| collection | DOAJ |
| description | Introduction: Gonadotropins are the main drugs for ovarian stimulation in assisted reproductive cycles. There are many different types of urine, purified or recombinant gonadotropins. This study was performed aimed to compare the clinical outcomes of two types of recombinant Cinal F gonadotropin Iranian company and Gonal F of foreign company.
Methods: This retrospective study was conducted in 2015-2019 on 521 infertile women (263 Cinal F and 258 Gonal F) who were referred to Milad Center affiliated to Mashhad University of Medical Sciences and were candidate for IVF. Clinical Outcomes including number of follicles, number of obtained oocytes, number of metaphase1 and 2 oocytes, number of high-quality embryos, rate of ovarian hyperstimulation syndrome, and positive pregnancy test were compared in Cinal F and Gonal F groups. Data were analyzed by SPSS statistical software (version 23) and Independent t-test and chi-square test. P<0.05 was considered statistically significant.
Results: The incidence of ovarian hyperstimulation syndrome and positive pregnancy test was not significantly different in the two groups (P> 0.05). In the Gonal F group, the percentage of good embryo quality was better than Cinal F group (p = 0.017). The number of total follicles and oocytes, metaphase 1 and 2 oocytes and the number of necrotic and low-quality oocytes, and the number of embryos and frozen embryos were not significantly different (P> 0.05).
Conclusion: In this study, there was no evidence in favor of the difference between cinal and foreign drug in the success rate of assisted reproductive cycles. Regarding to the scarcity and high cost of Gonal F, Cinal can be used with confidence in the IVF cycle. |
| first_indexed | 2024-04-11T07:04:31Z |
| format | Article |
| id | doaj.art-883ccd95222e4d699c764e7e9c91f5c8 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T07:04:31Z |
| publishDate | 2022-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-883ccd95222e4d699c764e7e9c91f5c82022-12-22T04:38:25ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632022-07-01255505710.22038/ijogi.2022.2079320793Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility CenterFaizeh Mashhadi0Malihe Mahmoudinia1Tahere Sadeghi2Nafiseh Jahanpak3Nayereh Khadem4General practitioner, Maternal & Neonatal Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Obstetrics and Gynecology, Maternal & Neonatal Health Research Center, Faculty of Medicines, Mashhad University of Medical Sciences, Mashhad, Iran.Assistant Professor, Department of Pediatrics Nursing, Nursing and Midwifery Care Research Center, School of Nursing And Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.M.Sc. in Midwifery, Maternal & Neonatal Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Professor, Department of Obstetrics and Gynecology, Maternal & Neonatal Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: Gonadotropins are the main drugs for ovarian stimulation in assisted reproductive cycles. There are many different types of urine, purified or recombinant gonadotropins. This study was performed aimed to compare the clinical outcomes of two types of recombinant Cinal F gonadotropin Iranian company and Gonal F of foreign company. Methods: This retrospective study was conducted in 2015-2019 on 521 infertile women (263 Cinal F and 258 Gonal F) who were referred to Milad Center affiliated to Mashhad University of Medical Sciences and were candidate for IVF. Clinical Outcomes including number of follicles, number of obtained oocytes, number of metaphase1 and 2 oocytes, number of high-quality embryos, rate of ovarian hyperstimulation syndrome, and positive pregnancy test were compared in Cinal F and Gonal F groups. Data were analyzed by SPSS statistical software (version 23) and Independent t-test and chi-square test. P<0.05 was considered statistically significant. Results: The incidence of ovarian hyperstimulation syndrome and positive pregnancy test was not significantly different in the two groups (P> 0.05). In the Gonal F group, the percentage of good embryo quality was better than Cinal F group (p = 0.017). The number of total follicles and oocytes, metaphase 1 and 2 oocytes and the number of necrotic and low-quality oocytes, and the number of embryos and frozen embryos were not significantly different (P> 0.05). Conclusion: In this study, there was no evidence in favor of the difference between cinal and foreign drug in the success rate of assisted reproductive cycles. Regarding to the scarcity and high cost of Gonal F, Cinal can be used with confidence in the IVF cycle.https://ijogi.mums.ac.ir/article_20793_40ef1c6cd9e76918887ed9fb5d6ca4f4.pdfembryo qualitygonadotropinivfoocyte qualitypregnancy rate |
| spellingShingle | Faizeh Mashhadi Malihe Mahmoudinia Tahere Sadeghi Nafiseh Jahanpak Nayereh Khadem Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān embryo quality gonadotropin ivf oocyte quality pregnancy rate |
| title | Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center |
| title_full | Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center |
| title_fullStr | Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center |
| title_full_unstemmed | Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center |
| title_short | Gonal F and Cinal F drugs on infertility treatment in ICSI cycle in Milad Infertility Center |
| title_sort | gonal f and cinal f drugs on infertility treatment in icsi cycle in milad infertility center |
| topic | embryo quality gonadotropin ivf oocyte quality pregnancy rate |
| url | https://ijogi.mums.ac.ir/article_20793_40ef1c6cd9e76918887ed9fb5d6ca4f4.pdf |
| work_keys_str_mv | AT faizehmashhadi gonalfandcinalfdrugsoninfertilitytreatmentinicsicycleinmiladinfertilitycenter AT malihemahmoudinia gonalfandcinalfdrugsoninfertilitytreatmentinicsicycleinmiladinfertilitycenter AT taheresadeghi gonalfandcinalfdrugsoninfertilitytreatmentinicsicycleinmiladinfertilitycenter AT nafisehjahanpak gonalfandcinalfdrugsoninfertilitytreatmentinicsicycleinmiladinfertilitycenter AT nayerehkhadem gonalfandcinalfdrugsoninfertilitytreatmentinicsicycleinmiladinfertilitycenter |