Microbial Oligosaccharides with Biomedical Applications
Microbial oligosaccharides have been regarded as one of the most appealing natural products attributable to their potent and selective bioactivities, such as antimicrobial activity, inhibition of α-glucosidases and lipase, interference of cellular recognition and signal transduction, and disruption...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/6/350 |
| _version_ | 1797529433285853184 |
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| author | Jian-Lin Xu Zhi-Feng Liu Xiao-Wei Zhang Hai-Li Liu Yong Wang |
| author_facet | Jian-Lin Xu Zhi-Feng Liu Xiao-Wei Zhang Hai-Li Liu Yong Wang |
| author_sort | Jian-Lin Xu |
| collection | DOAJ |
| description | Microbial oligosaccharides have been regarded as one of the most appealing natural products attributable to their potent and selective bioactivities, such as antimicrobial activity, inhibition of α-glucosidases and lipase, interference of cellular recognition and signal transduction, and disruption of cell wall biosynthesis. Accordingly, a handful of bioactive oligosaccharides have been developed for the treatment of bacterial infections and type II diabetes mellitus. Given that naturally occurring oligosaccharides have increasingly gained recognition in recent years, a comprehensive review is needed. The current review highlights the chemical structures, biological activities and divergent biosynthetic origins of three subgroups of oligomers including the acarviosine-containing oligosaccharides, saccharomicins, and orthosomycins. |
| first_indexed | 2024-03-10T10:13:48Z |
| format | Article |
| id | doaj.art-883da24b6e5b4ecb969865ffb6ea2994 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T10:13:48Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-883da24b6e5b4ecb969865ffb6ea29942023-11-22T00:58:28ZengMDPI AGMarine Drugs1660-33972021-06-0119635010.3390/md19060350Microbial Oligosaccharides with Biomedical ApplicationsJian-Lin Xu0Zhi-Feng Liu1Xiao-Wei Zhang2Hai-Li Liu3Yong Wang4Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, ChinaKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, ChinaKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, ChinaKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, ChinaKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, ChinaMicrobial oligosaccharides have been regarded as one of the most appealing natural products attributable to their potent and selective bioactivities, such as antimicrobial activity, inhibition of α-glucosidases and lipase, interference of cellular recognition and signal transduction, and disruption of cell wall biosynthesis. Accordingly, a handful of bioactive oligosaccharides have been developed for the treatment of bacterial infections and type II diabetes mellitus. Given that naturally occurring oligosaccharides have increasingly gained recognition in recent years, a comprehensive review is needed. The current review highlights the chemical structures, biological activities and divergent biosynthetic origins of three subgroups of oligomers including the acarviosine-containing oligosaccharides, saccharomicins, and orthosomycins.https://www.mdpi.com/1660-3397/19/6/350microbial oligosaccharideaminooligosaccharidesaccharomicinorthosomycinchemical structurebiomedical applications |
| spellingShingle | Jian-Lin Xu Zhi-Feng Liu Xiao-Wei Zhang Hai-Li Liu Yong Wang Microbial Oligosaccharides with Biomedical Applications Marine Drugs microbial oligosaccharide aminooligosaccharide saccharomicin orthosomycin chemical structure biomedical applications |
| title | Microbial Oligosaccharides with Biomedical Applications |
| title_full | Microbial Oligosaccharides with Biomedical Applications |
| title_fullStr | Microbial Oligosaccharides with Biomedical Applications |
| title_full_unstemmed | Microbial Oligosaccharides with Biomedical Applications |
| title_short | Microbial Oligosaccharides with Biomedical Applications |
| title_sort | microbial oligosaccharides with biomedical applications |
| topic | microbial oligosaccharide aminooligosaccharide saccharomicin orthosomycin chemical structure biomedical applications |
| url | https://www.mdpi.com/1660-3397/19/6/350 |
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