Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin
Pyoderma gangrenosum (PG) is a rare noninfectious autoinflammatory neutrophilic dermatoses occurring in 5%–12% of patients with ulcerative colitis (UC). Clinically, it is classified into ulcerative, pustular, bullous, and vegetative types. A few atypical and rare variants have also been described. T...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Clinical Dermatology Review |
| Subjects: | |
| Online Access: | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2024;volume=8;issue=1;spage=73;epage=75;aulast=Nayanathara |
| _version_ | 1797300091948630016 |
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| author | G S Nayanathara Varadraj Vasant Pai Rakhi Ghodge |
| author_facet | G S Nayanathara Varadraj Vasant Pai Rakhi Ghodge |
| author_sort | G S Nayanathara |
| collection | DOAJ |
| description | Pyoderma gangrenosum (PG) is a rare noninfectious autoinflammatory neutrophilic dermatoses occurring in 5%–12% of patients with ulcerative colitis (UC). Clinically, it is classified into ulcerative, pustular, bullous, and vegetative types. A few atypical and rare variants have also been described. The disease is characterized by painful cutaneous ulcers and is often associated with systemic diseases. Inflammatory bowel disease may precede it, follow it or occur simultaneously with PG. In some patients, control of bowel disease also leads to control of PG, but this does not occur in all patients. The mainstay of treatment is long-term immunosuppression with corticosteroids or ciclosporin. Herein, we present a case of PG associated with UC in whom immunosuppressants are contraindicated, was treated successfully with IV immunoglobulins. |
| first_indexed | 2024-03-07T23:01:14Z |
| format | Article |
| id | doaj.art-883f3c4149574d3c9612dd5c9548f7ed |
| institution | Directory Open Access Journal |
| issn | 2542-551X 2542-5528 |
| language | English |
| last_indexed | 2024-03-07T23:01:14Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj.art-883f3c4149574d3c9612dd5c9548f7ed2024-02-22T14:42:15ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282024-01-0181737510.4103/cdr.cdr_91_22Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulinG S NayanatharaVaradraj Vasant PaiRakhi GhodgePyoderma gangrenosum (PG) is a rare noninfectious autoinflammatory neutrophilic dermatoses occurring in 5%–12% of patients with ulcerative colitis (UC). Clinically, it is classified into ulcerative, pustular, bullous, and vegetative types. A few atypical and rare variants have also been described. The disease is characterized by painful cutaneous ulcers and is often associated with systemic diseases. Inflammatory bowel disease may precede it, follow it or occur simultaneously with PG. In some patients, control of bowel disease also leads to control of PG, but this does not occur in all patients. The mainstay of treatment is long-term immunosuppression with corticosteroids or ciclosporin. Herein, we present a case of PG associated with UC in whom immunosuppressants are contraindicated, was treated successfully with IV immunoglobulins.http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2024;volume=8;issue=1;spage=73;epage=75;aulast=Nayanatharaintravenous immunoglobulinpyoderma gangrenosumtuberculosis brain abscessulcerative colitis |
| spellingShingle | G S Nayanathara Varadraj Vasant Pai Rakhi Ghodge Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin Clinical Dermatology Review intravenous immunoglobulin pyoderma gangrenosum tuberculosis brain abscess ulcerative colitis |
| title | Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin |
| title_full | Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin |
| title_fullStr | Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin |
| title_full_unstemmed | Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin |
| title_short | Pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin |
| title_sort | pyoderma gangrenosum associated with ulcerative colitis and tuberculosis brain abscess successfully treated with intravenous immunoglobulin |
| topic | intravenous immunoglobulin pyoderma gangrenosum tuberculosis brain abscess ulcerative colitis |
| url | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2024;volume=8;issue=1;spage=73;epage=75;aulast=Nayanathara |
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