Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung
Distinguishing metastatic lung tumors from primary lung cancer is essential for planning the appropriate treatment strategy. Thyroid transcription factor-1 (TTF-1) is a reliable immunohistochemistry (IHC) marker for differentiating between primary lung adenocarcinomas and metastatic lung tumors orig...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007123000072 |
| _version_ | 1797870598688342016 |
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| author | Yusuke Takanashi Kiyotaka Kurachi Mayu Fujihiro Keigo Sekihara Kakeru Torii Akikazu Kawase Yuta Matsubayashi Takamitsu Hayakawa Satoshi Baba Haruhiko Sugimura Toshihide Iwashita Kazuhito Funai |
| author_facet | Yusuke Takanashi Kiyotaka Kurachi Mayu Fujihiro Keigo Sekihara Kakeru Torii Akikazu Kawase Yuta Matsubayashi Takamitsu Hayakawa Satoshi Baba Haruhiko Sugimura Toshihide Iwashita Kazuhito Funai |
| author_sort | Yusuke Takanashi |
| collection | DOAJ |
| description | Distinguishing metastatic lung tumors from primary lung cancer is essential for planning the appropriate treatment strategy. Thyroid transcription factor-1 (TTF-1) is a reliable immunohistochemistry (IHC) marker for differentiating between primary lung adenocarcinomas and metastatic lung tumors originating from colorectal adenocarcinomas. Herein, we report a rare case of TTF-1 expression in both the metastatic lung tumor and primary rectal adenocarcinoma. Aside from the similar histological characteristics of both tumors when stained with hematoxylin–eosin, the IHC patterns, including negative results for alveolar epithelium markers (napsin A and CK7) and positive results for intestinal markers (CK20, CDX2, SATB2, and β-catenin), of the lung tumor and the primary rectal adenocarcinoma strongly supported the final diagnosis. Considering the non-negligible frequency of TTF-1 positivity in colorectal adenocarcinomas, applying the IHC panel including multiple markers for alveolar epithelium and intestinal differentiation, would be helpful to support the diagnosis of metastatic lung tumor from a rectal adenocarcinoma. |
| first_indexed | 2024-04-10T00:29:57Z |
| format | Article |
| id | doaj.art-884223da056545199fd049fcd2199151 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-10T00:29:57Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-884223da056545199fd049fcd21991512023-03-15T04:28:05ZengElsevierRespiratory Medicine Case Reports2213-00712023-01-0142101812Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lungYusuke Takanashi0Kiyotaka Kurachi1Mayu Fujihiro2Keigo Sekihara3Kakeru Torii4Akikazu Kawase5Yuta Matsubayashi6Takamitsu Hayakawa7Satoshi Baba8Haruhiko Sugimura9Toshihide Iwashita10Kazuhito Funai11First Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanSecond Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanDepartment of Diagnostic Pathology, Hamamatsu University School of Medicine Hospital, Hamamatsu city, Shizuoka prefecture, JapanFirst Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanFirst Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanFirst Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanFirst Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanFirst Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanDepartment of Diagnostic Pathology, Hamamatsu University School of Medicine Hospital, Hamamatsu city, Shizuoka prefecture, JapanDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanDepartment of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, JapanFirst Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu city, Shizuoka prefecture, Japan; Corresponding author. First Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.Distinguishing metastatic lung tumors from primary lung cancer is essential for planning the appropriate treatment strategy. Thyroid transcription factor-1 (TTF-1) is a reliable immunohistochemistry (IHC) marker for differentiating between primary lung adenocarcinomas and metastatic lung tumors originating from colorectal adenocarcinomas. Herein, we report a rare case of TTF-1 expression in both the metastatic lung tumor and primary rectal adenocarcinoma. Aside from the similar histological characteristics of both tumors when stained with hematoxylin–eosin, the IHC patterns, including negative results for alveolar epithelium markers (napsin A and CK7) and positive results for intestinal markers (CK20, CDX2, SATB2, and β-catenin), of the lung tumor and the primary rectal adenocarcinoma strongly supported the final diagnosis. Considering the non-negligible frequency of TTF-1 positivity in colorectal adenocarcinomas, applying the IHC panel including multiple markers for alveolar epithelium and intestinal differentiation, would be helpful to support the diagnosis of metastatic lung tumor from a rectal adenocarcinoma.http://www.sciencedirect.com/science/article/pii/S2213007123000072Colorectal adenocarcinomaMetastatic lung tumorThyroid transcription factor-1 |
| spellingShingle | Yusuke Takanashi Kiyotaka Kurachi Mayu Fujihiro Keigo Sekihara Kakeru Torii Akikazu Kawase Yuta Matsubayashi Takamitsu Hayakawa Satoshi Baba Haruhiko Sugimura Toshihide Iwashita Kazuhito Funai Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung Respiratory Medicine Case Reports Colorectal adenocarcinoma Metastatic lung tumor Thyroid transcription factor-1 |
| title | Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung |
| title_full | Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung |
| title_fullStr | Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung |
| title_full_unstemmed | Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung |
| title_short | Thyroid transcription factor-1 expression in rectal adenocarcinoma metastatic to the lung |
| title_sort | thyroid transcription factor 1 expression in rectal adenocarcinoma metastatic to the lung |
| topic | Colorectal adenocarcinoma Metastatic lung tumor Thyroid transcription factor-1 |
| url | http://www.sciencedirect.com/science/article/pii/S2213007123000072 |
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