<i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet
<i>Salmonella</i> Typhimurium is widely distributed in food. It can colonise the gastrointestinal tract after ingestion, causing lamina propria edema, inflammatory cell infiltration, and mucosal epithelial decomposition. A high-fat diet (HFD) can induce an inflammatory response, but whet...
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MDPI AG
2021-12-01
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| Series: | Foods |
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| author | Zhongyue Ren Lingling Peng Shufang Chen Yi Pu Huihui Lv Hua Wei Cuixiang Wan |
| author_facet | Zhongyue Ren Lingling Peng Shufang Chen Yi Pu Huihui Lv Hua Wei Cuixiang Wan |
| author_sort | Zhongyue Ren |
| collection | DOAJ |
| description | <i>Salmonella</i> Typhimurium is widely distributed in food. It can colonise the gastrointestinal tract after ingestion, causing lamina propria edema, inflammatory cell infiltration, and mucosal epithelial decomposition. A high-fat diet (HFD) can induce an inflammatory response, but whether HFD can increase the infection level of <i>S.</i> Typhimurium is unknown. We established a model of <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Typhimurium strain ATCC 13311 ATCC 13311 infection in healthy adult mice with a maintenance diet (MD) or HFD to explore the effect of <i>Lactiplantibacillus plantarum</i> 1201 intervention on <i>S.</i> Typhimurium ATCC 13311 colonization and its protective effects on mice. HFD exacerbated the infection of <i>S.</i> Typhimurium ATCC 13311, while the intervention of <i>L. plantarum</i> 1201 effectively mitigated this process. <i>L. plantarum</i> 1201 can reduce the colonies of <i>S.</i> ATCC 13311 in the intestines and tissues; and reduce intestinal inflammation by down-regulating the level of TLR4/NF-κB pathway related proteins in serum and the expression of related inflammatory factors in the colon and jejunum. Since <i>L. plantarum</i> 1201 can inhibit the colonization of <i>S.</i> Typhimurium ATCC 13311 and relieve inflammation in HFD, current research may support the use of <i>L. plantarum</i> 1201 to prevent <i>S.</i> Typhimurium infection. |
| first_indexed | 2024-03-10T03:41:37Z |
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| language | English |
| last_indexed | 2024-03-10T03:41:37Z |
| publishDate | 2021-12-01 |
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| record_format | Article |
| series | Foods |
| spelling | doaj.art-88436cd4cb5749818e647c0c9f8796f52023-11-23T11:31:13ZengMDPI AGFoods2304-81582021-12-011118510.3390/foods11010085<i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat DietZhongyue Ren0Lingling Peng1Shufang Chen2Yi Pu3Huihui Lv4Hua Wei5Cuixiang Wan6State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaSchool of Food Science and Technology, Nanchang University, Nanchang 330047, China<i>Salmonella</i> Typhimurium is widely distributed in food. It can colonise the gastrointestinal tract after ingestion, causing lamina propria edema, inflammatory cell infiltration, and mucosal epithelial decomposition. A high-fat diet (HFD) can induce an inflammatory response, but whether HFD can increase the infection level of <i>S.</i> Typhimurium is unknown. We established a model of <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Typhimurium strain ATCC 13311 ATCC 13311 infection in healthy adult mice with a maintenance diet (MD) or HFD to explore the effect of <i>Lactiplantibacillus plantarum</i> 1201 intervention on <i>S.</i> Typhimurium ATCC 13311 colonization and its protective effects on mice. HFD exacerbated the infection of <i>S.</i> Typhimurium ATCC 13311, while the intervention of <i>L. plantarum</i> 1201 effectively mitigated this process. <i>L. plantarum</i> 1201 can reduce the colonies of <i>S.</i> ATCC 13311 in the intestines and tissues; and reduce intestinal inflammation by down-regulating the level of TLR4/NF-κB pathway related proteins in serum and the expression of related inflammatory factors in the colon and jejunum. Since <i>L. plantarum</i> 1201 can inhibit the colonization of <i>S.</i> Typhimurium ATCC 13311 and relieve inflammation in HFD, current research may support the use of <i>L. plantarum</i> 1201 to prevent <i>S.</i> Typhimurium infection.https://www.mdpi.com/2304-8158/11/1/85<i>Lactiplantibacillus plantarum</i> 1201<i>Salmonella</i> Typhimurium ATCC 13311high-fat dietintestinal infectioncolonizationinflammation |
| spellingShingle | Zhongyue Ren Lingling Peng Shufang Chen Yi Pu Huihui Lv Hua Wei Cuixiang Wan <i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet Foods <i>Lactiplantibacillus plantarum</i> 1201 <i>Salmonella</i> Typhimurium ATCC 13311 high-fat diet intestinal infection colonization inflammation |
| title | <i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet |
| title_full | <i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet |
| title_fullStr | <i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet |
| title_full_unstemmed | <i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet |
| title_short | <i>Lactiplantibacillus plantarum</i> 1201 Inhibits Intestinal Infection of <i>Salmonella enterica</i> subsp. <i>enterica</i> Serovar Typhimurium Strain ATCC 13311 in Mice with High-Fat Diet |
| title_sort | i lactiplantibacillus plantarum i 1201 inhibits intestinal infection of i salmonella enterica i subsp i enterica i serovar typhimurium strain atcc 13311 in mice with high fat diet |
| topic | <i>Lactiplantibacillus plantarum</i> 1201 <i>Salmonella</i> Typhimurium ATCC 13311 high-fat diet intestinal infection colonization inflammation |
| url | https://www.mdpi.com/2304-8158/11/1/85 |
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