Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia
AbstractPurpose The heating characteristics of water-filtered infrared-A (wIRA) radiation were investigated in vivo in two body regions of healthy humans according to the quality standards of the European Society for Hyperthermic Oncology (ESHO) using an irradiance (infrared-A) of 146 W m−2 as recom...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2244208 |
| _version_ | 1827397140897333248 |
|---|---|
| author | Helmut Piazena Peter Vaupel Andreas R. Thomsen |
| author_facet | Helmut Piazena Peter Vaupel Andreas R. Thomsen |
| author_sort | Helmut Piazena |
| collection | DOAJ |
| description | AbstractPurpose The heating characteristics of water-filtered infrared-A (wIRA) radiation were investigated in vivo in two body regions of healthy humans according to the quality standards of the European Society for Hyperthermic Oncology (ESHO) using an irradiance (infrared-A) of 146 W m−2 as recommended for clinical superficial hyperthermia (HT).Methods wIRA was applied to the abdominal wall and lumbar region for 60 min. Skin surface temperature was limited to ≤43 °C. Tissue temperatures were measured invasively at 1-min intervals before, during and after wIRA exposure using five fiber-optical probes at depths of 1–20 mm.Results Significant differences between body regions occurred during the heating-up phase at depths of 5–15 mm. Thermal steady states were reached at depths ≤5 mm after exposures of 5–6 min, and ≤20 mm after 20 min. On average, the minimum requirements of ESHO were exceeded in both regions by the following factors: ≈3 for the heating rate, ≈2 for the specific absorption rate and ≈1.4 for the temperature rise. Tissue depths with T90 ≥ 40 °C and T50 > 41 °C were ≤10 mm, and ≤20 mm for Tmax ≤ 43 °C. The temperature decay time after termination of irradiation was 1–5 min. Corresponding temperatures were ≤42.2 °C for CEM43 and ≤41.8 °C for CEM43T90, i.e., they are inadequate for direct thermal cell killing.Conclusions Thermography-controlled wIRA-HT complies with the ESHO criteria for superficial HT as a radiosensitizer and avoids the risk of thermal skin toxicity. |
| first_indexed | 2024-03-08T19:02:57Z |
| format | Article |
| id | doaj.art-8845fa1cae864ba8b638f8c5c6d84e85 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:57Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-8845fa1cae864ba8b638f8c5c6d84e852023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2023.2244208Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermiaHelmut Piazena0Peter Vaupel1Andreas R. Thomsen2Interdisciplinary Center of Sleep Medicine, Charité – University Medicine Berlin, Berlin, GermanyDepartment of Radiation Oncology, University Medical Center, University of Freiburg, Freiburg/Brsg, GermanyDepartment of Radiation Oncology, University Medical Center, University of Freiburg, Freiburg/Brsg, GermanyAbstractPurpose The heating characteristics of water-filtered infrared-A (wIRA) radiation were investigated in vivo in two body regions of healthy humans according to the quality standards of the European Society for Hyperthermic Oncology (ESHO) using an irradiance (infrared-A) of 146 W m−2 as recommended for clinical superficial hyperthermia (HT).Methods wIRA was applied to the abdominal wall and lumbar region for 60 min. Skin surface temperature was limited to ≤43 °C. Tissue temperatures were measured invasively at 1-min intervals before, during and after wIRA exposure using five fiber-optical probes at depths of 1–20 mm.Results Significant differences between body regions occurred during the heating-up phase at depths of 5–15 mm. Thermal steady states were reached at depths ≤5 mm after exposures of 5–6 min, and ≤20 mm after 20 min. On average, the minimum requirements of ESHO were exceeded in both regions by the following factors: ≈3 for the heating rate, ≈2 for the specific absorption rate and ≈1.4 for the temperature rise. Tissue depths with T90 ≥ 40 °C and T50 > 41 °C were ≤10 mm, and ≤20 mm for Tmax ≤ 43 °C. The temperature decay time after termination of irradiation was 1–5 min. Corresponding temperatures were ≤42.2 °C for CEM43 and ≤41.8 °C for CEM43T90, i.e., they are inadequate for direct thermal cell killing.Conclusions Thermography-controlled wIRA-HT complies with the ESHO criteria for superficial HT as a radiosensitizer and avoids the risk of thermal skin toxicity.https://www.tandfonline.com/doi/10.1080/02656736.2023.2244208Water-filtered infrared-A (wIRA) irradiationsuperficial hyperthermiamild hyperthermiatissue thermometryskin thermographyESHO guidelines |
| spellingShingle | Helmut Piazena Peter Vaupel Andreas R. Thomsen Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia International Journal of Hyperthermia Water-filtered infrared-A (wIRA) irradiation superficial hyperthermia mild hyperthermia tissue thermometry skin thermography ESHO guidelines |
| title | Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia |
| title_full | Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia |
| title_fullStr | Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia |
| title_full_unstemmed | Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia |
| title_short | Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia |
| title_sort | clinical wira hyperthermia heating properties and effectiveness in lower trunk regions and its accordance with esho quality criteria for superficial hyperthermia |
| topic | Water-filtered infrared-A (wIRA) irradiation superficial hyperthermia mild hyperthermia tissue thermometry skin thermography ESHO guidelines |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2244208 |
| work_keys_str_mv | AT helmutpiazena clinicalwirahyperthermiaheatingpropertiesandeffectivenessinlowertrunkregionsanditsaccordancewitheshoqualitycriteriaforsuperficialhyperthermia AT petervaupel clinicalwirahyperthermiaheatingpropertiesandeffectivenessinlowertrunkregionsanditsaccordancewitheshoqualitycriteriaforsuperficialhyperthermia AT andreasrthomsen clinicalwirahyperthermiaheatingpropertiesandeffectivenessinlowertrunkregionsanditsaccordancewitheshoqualitycriteriaforsuperficialhyperthermia |