Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia
Chronic eosinophilic leukemia-not otherwise specified (CEL-NOS) is a rare disorder with hypereosinophilia and an increase number of blood or marrow blasts (<20%) or an evidence of eosinophilic clonality. It is an aggressive disorder with a high rate of acute transformation and resistant to conven...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Journal of Applied Hematology |
| Subjects: | |
| Online Access: | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2015;volume=6;issue=3;spage=125;epage=129;aulast=Kasturi |
| _version_ | 1819071695149858816 |
|---|---|
| author | Kshitija Kasturi Sana Vanajakshi |
| author_facet | Kshitija Kasturi Sana Vanajakshi |
| author_sort | Kshitija Kasturi |
| collection | DOAJ |
| description | Chronic eosinophilic leukemia-not otherwise specified (CEL-NOS) is a rare disorder with hypereosinophilia and an increase number of blood or marrow blasts (<20%) or an evidence of eosinophilic clonality. It is an aggressive disorder with a high rate of acute transformation and resistant to conventional treatment. Its clinical and pathological picture vaguely overlap and adds to diagnostic confusion with idiopathic hypereosinophilic syndrome (IHES) which is characterized by sustained overproduction of eosinophils over a period of 6 months with multiple organ damage. Due to the difficulty in distinguishing CEL from IHES, the true incidence of this disease is rare. We report a case of CEL-NOS, which was preceded by IHES and terminated in acute myeloid leukemia with maturation (M2) in a 38-year-old male. |
| first_indexed | 2024-12-21T17:25:55Z |
| format | Article |
| id | doaj.art-884653a1ff93499497982e666b79c4b6 |
| institution | Directory Open Access Journal |
| issn | 1658-5127 |
| language | English |
| last_indexed | 2024-12-21T17:25:55Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj.art-884653a1ff93499497982e666b79c4b62022-12-21T18:56:03ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272015-01-016312512910.4103/1658-5127.162580Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemiaKshitija KasturiSana VanajakshiChronic eosinophilic leukemia-not otherwise specified (CEL-NOS) is a rare disorder with hypereosinophilia and an increase number of blood or marrow blasts (<20%) or an evidence of eosinophilic clonality. It is an aggressive disorder with a high rate of acute transformation and resistant to conventional treatment. Its clinical and pathological picture vaguely overlap and adds to diagnostic confusion with idiopathic hypereosinophilic syndrome (IHES) which is characterized by sustained overproduction of eosinophils over a period of 6 months with multiple organ damage. Due to the difficulty in distinguishing CEL from IHES, the true incidence of this disease is rare. We report a case of CEL-NOS, which was preceded by IHES and terminated in acute myeloid leukemia with maturation (M2) in a 38-year-old male.http://www.jahjournal.org/article.asp?issn=1658-5127;year=2015;volume=6;issue=3;spage=125;epage=129;aulast=KasturiAcute myeloid leukemia with maturationchronic eosinophilic leukemia-not otherwise specifiedidiopathic hypereosinophilic syndrome |
| spellingShingle | Kshitija Kasturi Sana Vanajakshi Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia Journal of Applied Hematology Acute myeloid leukemia with maturation chronic eosinophilic leukemia-not otherwise specified idiopathic hypereosinophilic syndrome |
| title | Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia |
| title_full | Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia |
| title_fullStr | Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia |
| title_full_unstemmed | Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia |
| title_short | Chronic eosinophilic leukemia-not otherwise specified transformation into acute myeloid leukemia |
| title_sort | chronic eosinophilic leukemia not otherwise specified transformation into acute myeloid leukemia |
| topic | Acute myeloid leukemia with maturation chronic eosinophilic leukemia-not otherwise specified idiopathic hypereosinophilic syndrome |
| url | http://www.jahjournal.org/article.asp?issn=1658-5127;year=2015;volume=6;issue=3;spage=125;epage=129;aulast=Kasturi |
| work_keys_str_mv | AT kshitijakasturi chroniceosinophilicleukemianototherwisespecifiedtransformationintoacutemyeloidleukemia AT sanavanajakshi chroniceosinophilicleukemianototherwisespecifiedtransformationintoacutemyeloidleukemia |