Crebanine induces ROS-dependent apoptosis in human hepatocellular carcinoma cells via the AKT/FoxO3a signaling pathway

Crebanine induces ROS-dependent apoptosis in human hepatocellular carcinoma cells via the AKT/FoxO3a signaling pathway

Background: Hepatocellular carcinoma (HCC), as an aggressive cancer with a high mortality rate, needs high-efficiency and low-toxicity drug therapy. Natural products have great potential as candidate lead compounds for the development of new HCC drugs. Crebanine is an isoquinoline alkaloid derived f...

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Bibliographic Details
Main Authors: Jiajie Tan, Yuling Xiang, Yuanguo Xiong, Yaoyuan Zhang, Boyang Qiao, Hong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
crebanine
reactive oxygen species
Akt
FoxO3a
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1069093/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1069093/full

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