Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

<p>Abstract</p> <p>Background</p> <p>PI3K and mTOR are key components of signal transduction pathways critical for cell survival. Numerous PI3K inhibitors have entered clinical trials, while mTOR is the target of approved drugs for metastatic renal cell carcinoma (RCC)....

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Bibliographic Details
Main Authors:	Maira Michel, Hackl Wolfgang, Siddiqui Summar, Conrad Patricia J, Aziz Saadia A, Elfiky Aymen A, Robert Camp L, Kluger Harriet M
Format:	Article
Language:	English
Published:	BMC 2011-08-01
Series:	Journal of Translational Medicine
Online Access:	http://www.translational-medicine.com/content/9/1/133

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