JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

Abstract Background Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK)...

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Bibliographic Details
Main Authors: Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Molecular Cancer
Subjects:
JMJD6
PAK1
MAPK
Melanoma
Alternative splicing
Online Access:http://link.springer.com/article/10.1186/s12943-017-0744-2

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