Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease
Purpose: The current study was carried out to evaluate the clinical features and management outcomes of dry eye disease (DED) in chronic ocular GvHD following allogenic hematopoietic stem cell transplantation (HSCT). Methods: A retrospective review of consecutive patients diagnosed with chronic ocul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1538;epage=1544;aulast=Kate |
| _version_ | 1827944853243166720 |
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| author | Anahita Kate Swati Singh Anthony Vipin Das Sayan Basu |
| author_facet | Anahita Kate Swati Singh Anthony Vipin Das Sayan Basu |
| author_sort | Anahita Kate |
| collection | DOAJ |
| description | Purpose: The current study was carried out to evaluate the clinical features and management outcomes of dry eye disease (DED) in chronic ocular GvHD following allogenic hematopoietic stem cell transplantation (HSCT). Methods: A retrospective review of consecutive patients diagnosed with chronic ocular GvHD between 2011 and 2020 was performed at a tertiary eye care network. Multi-variate regression analysis was carried out for identifying risk factors associated with progressive disease. Results: A total of 34 patients (68 eyes) with a median age of 33 years [inter-quartile range (IQR) 23–40.5] were studied. The most common indication for HSCT was acute lymphocytic leukemia (26%). Ocular GvHD developed at a median of 2 years (IQR 1–5.5 years) after HSCT. Aqueous tear deficiency was present in 71% of the eyes, of which 84% had a Schirmer value of <5 mm. The median visual acuity at presentation and that after a median follow-up of 6.9 months were comparable at 0.1 log minimum angle of resolution (logMAR) (P = 0.97). Topical immunosuppression was required in 88% of cases, and with this, improvement in corneal (53%, P = 0.003) and conjunctival staining scores (45%, P = 0.43) was noted. A progressive disease was present in 32% with persistent epithelial defects being the most common complication. Grade 2 conjunctival hyperemia [odds ratio (OR): 2.6; P = 0.01] and Schirmer's value <5 mm (OR: 2.7; P = 0.03) were found to be associated with progressive disease. Conclusion: Aqueous deficient DED is the most common ocular manifestation of chronic ocular GvHD, and the risk of the disease progression is greater in eyes with conjunctival hyperemia and severe aqueous deficiency. Awareness among ophthalmologists of this entity is essential for its timely detection and optimal management. |
| first_indexed | 2024-03-13T10:36:08Z |
| format | Article |
| id | doaj.art-8849011b5abd48b29dee2183abaca253 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-13T10:36:08Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-8849011b5abd48b29dee2183abaca2532023-05-18T05:50:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-017141538154410.4103/IJO.IJO_2820_22Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host diseaseAnahita KateSwati SinghAnthony Vipin DasSayan BasuPurpose: The current study was carried out to evaluate the clinical features and management outcomes of dry eye disease (DED) in chronic ocular GvHD following allogenic hematopoietic stem cell transplantation (HSCT). Methods: A retrospective review of consecutive patients diagnosed with chronic ocular GvHD between 2011 and 2020 was performed at a tertiary eye care network. Multi-variate regression analysis was carried out for identifying risk factors associated with progressive disease. Results: A total of 34 patients (68 eyes) with a median age of 33 years [inter-quartile range (IQR) 23–40.5] were studied. The most common indication for HSCT was acute lymphocytic leukemia (26%). Ocular GvHD developed at a median of 2 years (IQR 1–5.5 years) after HSCT. Aqueous tear deficiency was present in 71% of the eyes, of which 84% had a Schirmer value of <5 mm. The median visual acuity at presentation and that after a median follow-up of 6.9 months were comparable at 0.1 log minimum angle of resolution (logMAR) (P = 0.97). Topical immunosuppression was required in 88% of cases, and with this, improvement in corneal (53%, P = 0.003) and conjunctival staining scores (45%, P = 0.43) was noted. A progressive disease was present in 32% with persistent epithelial defects being the most common complication. Grade 2 conjunctival hyperemia [odds ratio (OR): 2.6; P = 0.01] and Schirmer's value <5 mm (OR: 2.7; P = 0.03) were found to be associated with progressive disease. Conclusion: Aqueous deficient DED is the most common ocular manifestation of chronic ocular GvHD, and the risk of the disease progression is greater in eyes with conjunctival hyperemia and severe aqueous deficiency. Awareness among ophthalmologists of this entity is essential for its timely detection and optimal management.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1538;epage=1544;aulast=Katechronic gvhddry eye diseasegraft-versus-host diseaseocular gvhdprogressionrisk factors |
| spellingShingle | Anahita Kate Swati Singh Anthony Vipin Das Sayan Basu Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease Indian Journal of Ophthalmology chronic gvhd dry eye disease graft-versus-host disease ocular gvhd progression risk factors |
| title | Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease |
| title_full | Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease |
| title_fullStr | Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease |
| title_full_unstemmed | Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease |
| title_short | Dry eye disease and risk factors for corneal complications in chronic ocular graft-versus-host disease |
| title_sort | dry eye disease and risk factors for corneal complications in chronic ocular graft versus host disease |
| topic | chronic gvhd dry eye disease graft-versus-host disease ocular gvhd progression risk factors |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=4;spage=1538;epage=1544;aulast=Kate |
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