The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis
<b>Background</b>: MCP-1 (monocyte chemoattractant protein) plays an important role in early phases of atherogenesis as well as in plaque destabilization, which causes cardiovascular events to play an important role in low-grade inflammation. Obesity, particularly extreme obesity, is a p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/7021 |
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| author | Tannaz Jamialahmadi Mitra Abbasifard Željko Reiner Prashant Kesharwani Amirhossein Sahebkar |
| author_facet | Tannaz Jamialahmadi Mitra Abbasifard Željko Reiner Prashant Kesharwani Amirhossein Sahebkar |
| author_sort | Tannaz Jamialahmadi |
| collection | DOAJ |
| description | <b>Background</b>: MCP-1 (monocyte chemoattractant protein) plays an important role in early phases of atherogenesis as well as in plaque destabilization, which causes cardiovascular events to play an important role in low-grade inflammation. Obesity, particularly extreme obesity, is a pivotal risk factor for atherosclerosis and many other diseases. In the early stages, bariatric surgery might stop or slow atherogenesis by suppressing inflammation, but also in later stages, preventing plaque destabilization. The aim of this meta-analysis was to provide an answer as to whether bariatric surgery has a significant effect on circulating MCP-1 level or not. <b>Methods</b>: A systematic literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to 1 January 2022. Meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V2 software. In order to heterogeneity compensation of studies in terms of study design and treatment duration, the characteristics of the studied populations random-effects model and the generic inverse variance weighting method were used. To investigate the relationship with the estimated effect size, a random-effect meta-regression model was used. To assess the exitance of publication bias in the meta-analysis, the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used. <b>Results</b>: Meta-analysis of 25 studies with 927 subjects included demonstrated a significant decrease of MCP-1 concentration after bariatric surgery. The data of meta-regression did not indicate any association between the alterations in body mass index (BMI) and absolute difference in MCP-1 levels, but a linear relationship between the changes in MCP-1 and length of follow-up was proven. <b>Conclusions</b>: Bariatric surgery significantly decreases MCP-1 concentration, but there was no association between the changes in BMI and absolute difference in MCP-1 levels before and after the surgery. |
| first_indexed | 2024-03-09T17:43:41Z |
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| id | doaj.art-884b650b5225458d9d9482e02b6da8f2 |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:41Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-884b650b5225458d9d9482e02b6da8f22023-11-24T11:21:35ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123702110.3390/jcm11237021The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-AnalysisTannaz Jamialahmadi0Mitra Abbasifard1Željko Reiner2Prashant Kesharwani3Amirhossein Sahebkar4Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranImmunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Internal Medicine, University Hospital Center Zagreb, 10000 Zagreb, CroatiaDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, IndiaApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran<b>Background</b>: MCP-1 (monocyte chemoattractant protein) plays an important role in early phases of atherogenesis as well as in plaque destabilization, which causes cardiovascular events to play an important role in low-grade inflammation. Obesity, particularly extreme obesity, is a pivotal risk factor for atherosclerosis and many other diseases. In the early stages, bariatric surgery might stop or slow atherogenesis by suppressing inflammation, but also in later stages, preventing plaque destabilization. The aim of this meta-analysis was to provide an answer as to whether bariatric surgery has a significant effect on circulating MCP-1 level or not. <b>Methods</b>: A systematic literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to 1 January 2022. Meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V2 software. In order to heterogeneity compensation of studies in terms of study design and treatment duration, the characteristics of the studied populations random-effects model and the generic inverse variance weighting method were used. To investigate the relationship with the estimated effect size, a random-effect meta-regression model was used. To assess the exitance of publication bias in the meta-analysis, the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used. <b>Results</b>: Meta-analysis of 25 studies with 927 subjects included demonstrated a significant decrease of MCP-1 concentration after bariatric surgery. The data of meta-regression did not indicate any association between the alterations in body mass index (BMI) and absolute difference in MCP-1 levels, but a linear relationship between the changes in MCP-1 and length of follow-up was proven. <b>Conclusions</b>: Bariatric surgery significantly decreases MCP-1 concentration, but there was no association between the changes in BMI and absolute difference in MCP-1 levels before and after the surgery.https://www.mdpi.com/2077-0383/11/23/7021obesitybariatric surgerymonocyte chemoattractant protein-1atherosclerosismeta-analysiscardiovascular disease |
| spellingShingle | Tannaz Jamialahmadi Mitra Abbasifard Željko Reiner Prashant Kesharwani Amirhossein Sahebkar The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis Journal of Clinical Medicine obesity bariatric surgery monocyte chemoattractant protein-1 atherosclerosis meta-analysis cardiovascular disease |
| title | The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis |
| title_full | The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis |
| title_fullStr | The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis |
| title_short | The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis |
| title_sort | effect of bariatric surgery on circulating levels of monocyte chemoattractant protein 1 a systematic review and meta analysis |
| topic | obesity bariatric surgery monocyte chemoattractant protein-1 atherosclerosis meta-analysis cardiovascular disease |
| url | https://www.mdpi.com/2077-0383/11/23/7021 |
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