ECM biomaterials for modeling of outflow cell biology in health and disease

ECM biomaterials for modeling of outflow cell biology in health and disease

This review highlights the importance of extracellular matrix (ECM) biomaterials in understanding the biology of human trabecular meshwork (TM) and Schlemm's canal (SC) cells under normal and simulated glaucoma-like conditions. We provide an overview of recent progress in the development and ap...

Full description

Bibliographic Details
Main Authors:	Souvik Ghosh, Samuel Herberg
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Series:	Biomaterials and Biosystems
Subjects:	Glaucoma Ocular hypertension Trabecular meshwork Schlemm's canal Outflow tract Hydrogel
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666534424000047

Similar Items

siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model
by: Paul S. Cassidy, et al.
Published: (2021-03-01)

Biomechanics of the JCT and SC Inner Wall Endothelial Cells with Their Basement Membrane Using 3D Serial Block-Face Scanning Electron Microscopy
by: Alireza Karimi, et al.
Published: (2023-09-01)

Endothelial Glycocalyx Morphology in Different Flow Regions of the Aqueous Outflow Pathway of Normal and Laser-Induced Glaucoma Monkey Eyes
by: Shayna Sosnowik, et al.
Published: (2022-08-01)

Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states
by: Revathi Balasubramanian, et al.
Published: (2024-10-01)

Effect of digital ocular massage on intraocular pressure and Schlemm’s canal dimensions
by: Tiffany H. Y. Wu, et al.
Published: (2024-03-01)

Modeling the Endothelial Glycocalyx Layer in the Human Conventional Aqueous Outflow Pathway
by: Alireza Karimi, et al.
Published: (2022-12-01)

Effects of Schlemm’s Canal Expansion: Biomechanics and MIGS Implications
by: Chen Xin, et al.
Published: (2021-02-01)

Investigational Rho Kinase Inhibitors for the Treatment of Glaucoma
by: Al-Humimat G, et al.
Published: (2021-02-01)

Anterior Scleral Thickness and Anterior Segment Biometrics Measured with Swept Source Ocular Coherence Tomography in High Myopic Eyes with and without Glaucoma: A Comparative Study
by: Bachar Kudsieh, et al.
Published: (2024-03-01)

Tissue-Engineered Models for Glaucoma Research
by: Renhao Lu, et al.
Published: (2020-06-01)

Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
by: Hannah C. Lamont, et al.
Published: (2021-10-01)

The anterior scleral thickness in primary open-angle glaucoma with high myopia
by: Mu Li, et al.
Published: (2024-06-01)

The Effects of Cannabidiol on Aqueous Humor Outflow and Trabecular Meshwork Cell Signaling
by: Alyssa S. Aebersold, et al.
Published: (2022-09-01)

Microinvasive Glaucoma Surgery: A Review of Schlemm’s Canal-Based Procedures
by: Konopińska J, et al.
Published: (2021-03-01)

Changes in Schlemm’s canal, trabecular meshwork, and relevant parameters in the early stage after SMILE of myopia patients
by: Dan-Dan Yang, et al.
Published: (2022-02-01)

Expression of matrix Metalloproteinases-2 and aquaporin-1 in corneoscleral junction after angle-closure in rabbits
by: Yaqin Jiang, et al.
Published: (2019-02-01)

The Effect of Intraocular Pressure Load Boundary on the Biomechanics of the Human Conventional Aqueous Outflow Pathway
by: Alireza Karimi, et al.
Published: (2022-11-01)

Development and Application of a New T-shaped Internal Trabeculotomy Hook (T-hook)
by: Chihara E, et al.
Published: (2022-11-01)

Exploiting biomaterial approaches to manufacture an artificial trabecular meshwork: A progress report
by: Devon J. Crouch, et al.
Published: (2021-03-01)

A Closer Look at Schlemm’s Canal Cell Physiology: Implications for Biomimetics
by: Cula N. Dautriche, et al.
Published: (2015-09-01)

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis
by: Guorong Li, et al.
Published: (2021-03-01)

Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells
by: Mark S. Filla, et al.
Published: (2021-07-01)

Preclinical Investigation of Goniotomy Using Four Different Techniques
by: Ammar DA, et al.
Published: (2020-10-01)

Comparison of the extracellular vesicle proteome between glaucoma and non-glaucoma trabecular meshwork cells
by: Fiona S. McDonnell, et al.
Published: (2023-10-01)

Spotlight on Schlemm’s Canal MicroStent Injection in Patients with Glaucoma
by: Wagner IV, et al.
Published: (2023-06-01)

Roles of Prostaglandins and Hydrogen Sulfide in an Outflow Model of the Porcine Ocular Anterior Segment Ex Vivo
by: Jenaye Robinson, et al.
Published: (2024-09-01)

Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions
by: Avinash Soundararajan, et al.
Published: (2022-09-01)

Dexamethasone Impairs ATP Production and Mitochondrial Performance in Human Trabecular Meshwork Cells
by: Shane Kennedy, et al.
Published: (2024-09-01)

Short-Term Efficacy of Combined ab Interno Canaloplasty and Trabeculotomy in Pseudophakic Eyes with Open-Angle Glaucoma
by: Bleeker AR, et al.
Published: (2022-07-01)

Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork/Schlemm’s Canal
by: Jennifer A. Faralli, et al.
Published: (2022-04-01)

Emergent Temporal Signaling in Human Trabecular Meshwork Cells: Role of TRPV4-TRPM4 Interactions
by: Oleg Yarishkin, et al.
Published: (2022-03-01)

The S341P mutant MYOC renders the trabecular meshwork sensitive to cyclic mechanical stretch
by: Xuejing Yan, et al.
Published: (2024-09-01)

Dexamethasone Modulates the Dynamics of Wnt Signaling in Human Trabecular Meshwork Cells
by: Chi Zhang, et al.
Published: (2023-05-01)

Preclinical Investigation of Ab Interno Goniotomy Using Three Different Techniques
by: Ammar DA, et al.
Published: (2023-09-01)

Transcriptome analysis for the identification of cellular markers related to trabecular meshwork differentiation
by: Padmapriya Sathiyanathan, et al.
Published: (2017-05-01)

Regeneration of trabecular meshwork in primary open angle glaucoma by stem cell therapy: a new treatment approach
by: Vingolo EM, et al.
Published: (2019-04-01)

Data on differentially expressed proteins in rock inhibitor-treated human trabecular meshwork cells using SWATH-based proteomics
by: Sze-Wan Shan, et al.
Published: (2020-08-01)

Matrix Metalloproteinases and Glaucoma
by: Moo Hyun Kim, et al.
Published: (2022-09-01)

The TGFβ Induced MicroRNAome of the Trabecular Meshwork
by: Chelsey Doyle, et al.
Published: (2024-06-01)

Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber
by: Hongxia, et al.
Published: (2019-04-01)