<i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice
The aim of the presented study was to investigate the synbiotic effects of <i>L. rhamnosus</i> 4B15 and <i>C. tricuspidata</i> extract administration on the gut microbiota and obesity-associated metabolic parameters in diet-induced obese mice. Thirty-one 6-week-old male C57BL...
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MDPI AG
2021-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/9/1908 |
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| author | Ju Kyoung Oh Robie Vasquez In-Chan Hwang Ye Na Oh Sang Hoon Kim Shin Ho Kang Jae Yeon Joung Nam Su Oh Sejeong Kim Yohan Yoon Dae-Kyung Kang |
| author_facet | Ju Kyoung Oh Robie Vasquez In-Chan Hwang Ye Na Oh Sang Hoon Kim Shin Ho Kang Jae Yeon Joung Nam Su Oh Sejeong Kim Yohan Yoon Dae-Kyung Kang |
| author_sort | Ju Kyoung Oh |
| collection | DOAJ |
| description | The aim of the presented study was to investigate the synbiotic effects of <i>L. rhamnosus</i> 4B15 and <i>C. tricuspidata</i> extract administration on the gut microbiota and obesity-associated metabolic parameters in diet-induced obese mice. Thirty-one 6-week-old male C57BL/N6 mice were divided into five diet groups: normal diet (ND, <i>n</i> = 7) group; high-fat diet (HFD, <i>n</i> = 6) group; probiotic (PRO, <i>n</i> = 5) group; prebiotic (PRE, <i>n</i> = 7) group; and synbiotic (SYN, <i>n</i> = 6) group. After 10 weeks, the percent of fat mass, serum triglyceride, and ALT levels were significantly reduced in SYN-fed obese mice, compared with other treatments. SYN treatment also modulated the abundance of <i>Desulfovibrio</i>, <i>Dorea</i>, <i>Adlercreutzia</i>, <i>Allobaculum</i>, <i>Coprococcus</i>, unclassified Clostridiaceae, <i>Lactobacillus</i>, <i>Helicobacter</i>, <i>Flexispira</i>, <i>Odoribacter</i>, <i>Ruminococcus</i>, unclassified Erysipelotrichaceae, and unclassified Desulfovibrionaceae. These taxa showed a strong correlation with obesity-associated indices. Lastly, the SYN-supplemented diet upregulated metabolic pathways known to improve metabolic health. Further investigations are needed to understand the mechanisms driving the synbiotic effect of <i>C. tricuspidata</i> and <i>L. rhamnosus</i> 4B15. |
| first_indexed | 2024-03-10T07:25:15Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T07:25:15Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-884da490a1ea498da144e5b78d2921dd2023-11-22T14:18:55ZengMDPI AGMicroorganisms2076-26072021-09-0199190810.3390/microorganisms9091908<i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese MiceJu Kyoung Oh0Robie Vasquez1In-Chan Hwang2Ye Na Oh3Sang Hoon Kim4Shin Ho Kang5Jae Yeon Joung6Nam Su Oh7Sejeong Kim8Yohan Yoon9Dae-Kyung Kang10Department of Animal Resources Science, Dankook University, Cheonan 31116, KoreaDepartment of Animal Resources Science, Dankook University, Cheonan 31116, KoreaDepartment of Animal Resources Science, Dankook University, Cheonan 31116, KoreaDepartment of Animal Resources Science, Dankook University, Cheonan 31116, KoreaDepartment of Animal Resources Science, Dankook University, Cheonan 31116, KoreaR&D Center, Seoul Dairy Cooperative, Ansan 15407, KoreaR&D Center, Seoul Dairy Cooperative, Ansan 15407, KoreaDepartment of Food and Biotechnology, Korea University Sejong Campus, Sejong 30019, KoreaDepartment of Food and Nutrition, Sookmyung Women’s University, Seoul 04310, KoreaDepartment of Food and Nutrition, Sookmyung Women’s University, Seoul 04310, KoreaDepartment of Animal Resources Science, Dankook University, Cheonan 31116, KoreaThe aim of the presented study was to investigate the synbiotic effects of <i>L. rhamnosus</i> 4B15 and <i>C. tricuspidata</i> extract administration on the gut microbiota and obesity-associated metabolic parameters in diet-induced obese mice. Thirty-one 6-week-old male C57BL/N6 mice were divided into five diet groups: normal diet (ND, <i>n</i> = 7) group; high-fat diet (HFD, <i>n</i> = 6) group; probiotic (PRO, <i>n</i> = 5) group; prebiotic (PRE, <i>n</i> = 7) group; and synbiotic (SYN, <i>n</i> = 6) group. After 10 weeks, the percent of fat mass, serum triglyceride, and ALT levels were significantly reduced in SYN-fed obese mice, compared with other treatments. SYN treatment also modulated the abundance of <i>Desulfovibrio</i>, <i>Dorea</i>, <i>Adlercreutzia</i>, <i>Allobaculum</i>, <i>Coprococcus</i>, unclassified Clostridiaceae, <i>Lactobacillus</i>, <i>Helicobacter</i>, <i>Flexispira</i>, <i>Odoribacter</i>, <i>Ruminococcus</i>, unclassified Erysipelotrichaceae, and unclassified Desulfovibrionaceae. These taxa showed a strong correlation with obesity-associated indices. Lastly, the SYN-supplemented diet upregulated metabolic pathways known to improve metabolic health. Further investigations are needed to understand the mechanisms driving the synbiotic effect of <i>C. tricuspidata</i> and <i>L. rhamnosus</i> 4B15.https://www.mdpi.com/2076-2607/9/9/1908obesity<i>Lacticaseibacillus rhamnosus</i> 4B15<i>Cudrania tricuspidata</i>gut microbiotametabolic disorderprobiotic |
| spellingShingle | Ju Kyoung Oh Robie Vasquez In-Chan Hwang Ye Na Oh Sang Hoon Kim Shin Ho Kang Jae Yeon Joung Nam Su Oh Sejeong Kim Yohan Yoon Dae-Kyung Kang <i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice Microorganisms obesity <i>Lacticaseibacillus rhamnosus</i> 4B15 <i>Cudrania tricuspidata</i> gut microbiota metabolic disorder probiotic |
| title | <i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice |
| title_full | <i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice |
| title_fullStr | <i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice |
| title_full_unstemmed | <i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice |
| title_short | <i>Cudrania tricuspidata</i> Combined with <i>Lacticaseibacillus rhamnosus</i> Modulate Gut Microbiota and Alleviate Obesity-Associated Metabolic Parameters in Obese Mice |
| title_sort | i cudrania tricuspidata i combined with i lacticaseibacillus rhamnosus i modulate gut microbiota and alleviate obesity associated metabolic parameters in obese mice |
| topic | obesity <i>Lacticaseibacillus rhamnosus</i> 4B15 <i>Cudrania tricuspidata</i> gut microbiota metabolic disorder probiotic |
| url | https://www.mdpi.com/2076-2607/9/9/1908 |
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