The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials.
BACKGROUND: The acute effects of grape polyphenols on endothelial function in adults are inconsistent. Here, we performed meta-analyses to determine these acute effects as measured by flow-mediated dilation (FMD). METHODS: Trials were searched in PubMed, Embase and the Cochrane Library database. Sum...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3722169?pdf=render |
| _version_ | 1811227996090007552 |
|---|---|
| author | Shao-Hua Li Hong-Bo Tian Hong-Jin Zhao Liang-Hua Chen Lian-Qun Cui |
| author_facet | Shao-Hua Li Hong-Bo Tian Hong-Jin Zhao Liang-Hua Chen Lian-Qun Cui |
| author_sort | Shao-Hua Li |
| collection | DOAJ |
| description | BACKGROUND: The acute effects of grape polyphenols on endothelial function in adults are inconsistent. Here, we performed meta-analyses to determine these acute effects as measured by flow-mediated dilation (FMD). METHODS: Trials were searched in PubMed, Embase and the Cochrane Library database. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the PROSPERO register and our registration number is CRD42013004157. RESULTS: Nine studies were included in the present meta-analyses. The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls. Meta-regression and subgroup analyses were performed and showed that a health status was the main effect modifier of the significant heterogeneity. Subgroups indicated that intake of grape polyphenols could significantly increase FMD in healthy subjects, and the increased FMD appeared to be more obviously in subjects with high cardiovascular risk factors. Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion. CONCLUSIONS: Endothelial function can be significantly improved in healthy adults in the initial 2 h after intake of grape polyphenols. The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects. |
| first_indexed | 2024-04-12T09:51:04Z |
| format | Article |
| id | doaj.art-884ecba24dc548b5a07f6eb28732a474 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T09:51:04Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-884ecba24dc548b5a07f6eb28732a4742022-12-22T03:37:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6981810.1371/journal.pone.0069818The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials.Shao-Hua LiHong-Bo TianHong-Jin ZhaoLiang-Hua ChenLian-Qun CuiBACKGROUND: The acute effects of grape polyphenols on endothelial function in adults are inconsistent. Here, we performed meta-analyses to determine these acute effects as measured by flow-mediated dilation (FMD). METHODS: Trials were searched in PubMed, Embase and the Cochrane Library database. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. The protocol details of our meta-analysis have been submitted to the PROSPERO register and our registration number is CRD42013004157. RESULTS: Nine studies were included in the present meta-analyses. The results showed that the FMD level was significantly increased in the initial 120 min after intake of grape polyphenols as compared with controls. Meta-regression and subgroup analyses were performed and showed that a health status was the main effect modifier of the significant heterogeneity. Subgroups indicated that intake of grape polyphenols could significantly increase FMD in healthy subjects, and the increased FMD appeared to be more obviously in subjects with high cardiovascular risk factors. Moreover, the peak effect of grape polyphenols on FMD in healthy subjects was found 30 min after ingestion, which was different from the effect in subjects with high cardiovascular risk factors, in whom the peak effect was found 60 min after ingestion. CONCLUSIONS: Endothelial function can be significantly improved in healthy adults in the initial 2 h after intake of grape polyphenols. The acute effect of grape polyphenols on endothelial function may be more significant but the peak effect is delayed in subjects with a smoking history or coronary heart disease as compared with the healthy subjects.http://europepmc.org/articles/PMC3722169?pdf=render |
| spellingShingle | Shao-Hua Li Hong-Bo Tian Hong-Jin Zhao Liang-Hua Chen Lian-Qun Cui The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. PLoS ONE |
| title | The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. |
| title_full | The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. |
| title_fullStr | The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. |
| title_full_unstemmed | The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. |
| title_short | The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials. |
| title_sort | acute effects of grape polyphenols supplementation on endothelial function in adults meta analyses of controlled trials |
| url | http://europepmc.org/articles/PMC3722169?pdf=render |
| work_keys_str_mv | AT shaohuali theacuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT hongbotian theacuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT hongjinzhao theacuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT lianghuachen theacuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT lianquncui theacuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT shaohuali acuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT hongbotian acuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT hongjinzhao acuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT lianghuachen acuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials AT lianquncui acuteeffectsofgrapepolyphenolssupplementationonendothelialfunctioninadultsmetaanalysesofcontrolledtrials |