Cathelicidin-trypsin inhibitor loop conjugate represents a promising antibiotic candidate with protease stability
Abstract Cathelicidins are regarded as promising antibiotics due to their capability against antibiotic-resistant bacteria without cytotoxicity. However, some concerns about the balance of cytotoxicity and antimicrobial activity, weak stability and enzymatic susceptibility sually restrict their ther...
Main Authors: | Haining Yu, Chen Wang, Lan Feng, Shasha Cai, Xuelian Liu, Xue Qiao, Nannan Shi, Hui Wang, Yipeng Wang |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2017-06-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-02050-2 |
Similar Items
-
Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design.
by: Guiying Ling, et al.
Published: (2014-01-01) -
Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics.
by: Yipeng Wang, et al.
Published: (2008-01-01) -
Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris.
by: Yipeng Wang, et al.
Published: (2011-01-01) -
Trypsin inhibitors: promising candidate satietogenic proteins as complementary treatment for obesity and metabolic disorders?
by: Vanessa Cristina Oliveira de Lima, et al.
Published: (2019-01-01) -
N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding
by: Hao Wang, et al.
Published: (2018-06-01)