The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes
Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing <i>Enterobacterales</i> (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenema...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/10/699 |
| _version_ | 1797550942641455104 |
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| author | Florence Hammer-Dedet Estelle Jumas-Bilak Patricia Licznar-Fajardo |
| author_facet | Florence Hammer-Dedet Estelle Jumas-Bilak Patricia Licznar-Fajardo |
| author_sort | Florence Hammer-Dedet |
| collection | DOAJ |
| description | Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing <i>Enterobacterales</i> (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (CEG) within clinical relevant bacteria is attributed in part to its location onto mobile genetic elements. During the last decade, carbapenemase producing bacteria have been isolated from non-human sources including the aquatic environment. Aquatic ecosystems are particularly impacted by anthropic activities, which conduce to a bidirectional exchange between aquatic environments and human beings and therefore the aquatic environment may constitute a hub for CPE and CEG. More recently, the isolation of autochtonous aquatic bacteria carrying acquired CEG have been reported and suggest that CEG exchange by horizontal gene transfer occurred between allochtonous and autochtonous bacteria. Hence, aquatic environment plays a central role in persistence, dissemination and emergence of CEG both within environmental ecosystem and human beings, and deserves to be studied with particular attention. |
| first_indexed | 2024-03-10T15:37:38Z |
| format | Article |
| id | doaj.art-885037a5e22e4ff191fc859f57f4609c |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T15:37:38Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-885037a5e22e4ff191fc859f57f4609c2023-11-20T17:08:26ZengMDPI AGAntibiotics2079-63822020-10-0191069910.3390/antibiotics9100699The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding GenesFlorence Hammer-Dedet0Estelle Jumas-Bilak1Patricia Licznar-Fajardo2UMR 5569 HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, 34090 Montpellier, FranceUMR 5569 HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, 34090 Montpellier, FranceUMR 5569 HydroSciences Montpellier, Université de Montpellier, CNRS, IRD, 34090 Montpellier, FranceCarbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing <i>Enterobacterales</i> (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (CEG) within clinical relevant bacteria is attributed in part to its location onto mobile genetic elements. During the last decade, carbapenemase producing bacteria have been isolated from non-human sources including the aquatic environment. Aquatic ecosystems are particularly impacted by anthropic activities, which conduce to a bidirectional exchange between aquatic environments and human beings and therefore the aquatic environment may constitute a hub for CPE and CEG. More recently, the isolation of autochtonous aquatic bacteria carrying acquired CEG have been reported and suggest that CEG exchange by horizontal gene transfer occurred between allochtonous and autochtonous bacteria. Hence, aquatic environment plays a central role in persistence, dissemination and emergence of CEG both within environmental ecosystem and human beings, and deserves to be studied with particular attention.https://www.mdpi.com/2079-6382/9/10/699carbapenemaseaquatic environmentone-healthhorizontal gene transfer |
| spellingShingle | Florence Hammer-Dedet Estelle Jumas-Bilak Patricia Licznar-Fajardo The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes Antibiotics carbapenemase aquatic environment one-health horizontal gene transfer |
| title | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
| title_full | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
| title_fullStr | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
| title_full_unstemmed | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
| title_short | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
| title_sort | hydric environment a hub for clinically relevant carbapenemase encoding genes |
| topic | carbapenemase aquatic environment one-health horizontal gene transfer |
| url | https://www.mdpi.com/2079-6382/9/10/699 |
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