An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections
The rise in antibiotic-resistant strains of clinically important pathogens is a major threat to global health. The World Health Organization (WHO) has recognized the urgent need to develop alternative treatments to address the growing list of priority pathogens. Antimicrobial peptides (AMPs) rank am...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/9/1281 |
| _version_ | 1827724560111239168 |
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| author | Karyne Rangel Guilherme Curty Lechuga David W. Provance Carlos M. Morel Salvatore G. De Simone |
| author_facet | Karyne Rangel Guilherme Curty Lechuga David W. Provance Carlos M. Morel Salvatore G. De Simone |
| author_sort | Karyne Rangel |
| collection | DOAJ |
| description | The rise in antibiotic-resistant strains of clinically important pathogens is a major threat to global health. The World Health Organization (WHO) has recognized the urgent need to develop alternative treatments to address the growing list of priority pathogens. Antimicrobial peptides (AMPs) rank among the suggested options with proven activity and high potential to be developed into effective drugs. Many AMPs are naturally produced by living organisms protecting the host against pathogens as a part of their innate immunity. Mechanisms associated with AMP actions include cell membrane disruption, cell wall weakening, protein synthesis inhibition, and interference in nucleic acid dynamics, inducing apoptosis and necrosis. <i>Acinetobacter baumannii</i> is a critical pathogen, as severe clinical implications have developed from isolates resistant to current antibiotic treatments and conventional control procedures, such as UV light, disinfectants, and drying. Here, we review the natural AMPs representing primary candidates for new anti-<i>A. baumannii</i> drugs in post-antibiotic-era and present computational tools to develop the next generation of AMPs with greater microbicidal activity and reduced toxicity. |
| first_indexed | 2024-03-10T22:16:32Z |
| format | Article |
| id | doaj.art-8850b9babfd34f26ac7cfe173c65b72b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T22:16:32Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-8850b9babfd34f26ac7cfe173c65b72b2023-11-19T12:25:07ZengMDPI AGPharmaceuticals1424-82472023-09-01169128110.3390/ph16091281An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> InfectionsKaryne Rangel0Guilherme Curty Lechuga1David W. Provance2Carlos M. Morel3Salvatore G. De Simone4Center for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Institut, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, BrazilCenter for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Institut, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, BrazilCenter for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Institut, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, BrazilCenter for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Institut, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, BrazilCenter for Technological Development in Health (CDTS), National Institute of Science and Technology for Innovation in Neglected Population Diseases (INCT-IDPN), Oswaldo Cruz Institut, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, BrazilThe rise in antibiotic-resistant strains of clinically important pathogens is a major threat to global health. The World Health Organization (WHO) has recognized the urgent need to develop alternative treatments to address the growing list of priority pathogens. Antimicrobial peptides (AMPs) rank among the suggested options with proven activity and high potential to be developed into effective drugs. Many AMPs are naturally produced by living organisms protecting the host against pathogens as a part of their innate immunity. Mechanisms associated with AMP actions include cell membrane disruption, cell wall weakening, protein synthesis inhibition, and interference in nucleic acid dynamics, inducing apoptosis and necrosis. <i>Acinetobacter baumannii</i> is a critical pathogen, as severe clinical implications have developed from isolates resistant to current antibiotic treatments and conventional control procedures, such as UV light, disinfectants, and drying. Here, we review the natural AMPs representing primary candidates for new anti-<i>A. baumannii</i> drugs in post-antibiotic-era and present computational tools to develop the next generation of AMPs with greater microbicidal activity and reduced toxicity.https://www.mdpi.com/1424-8247/16/9/1281AMP<i>Acinetobacter baumannii</i>resistancemechanism of actionmechanism of action |
| spellingShingle | Karyne Rangel Guilherme Curty Lechuga David W. Provance Carlos M. Morel Salvatore G. De Simone An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections Pharmaceuticals AMP <i>Acinetobacter baumannii</i> resistance mechanism of action mechanism of action |
| title | An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections |
| title_full | An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections |
| title_fullStr | An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections |
| title_full_unstemmed | An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections |
| title_short | An Update on the Therapeutic Potential of Antimicrobial Peptides against <i>Acinetobacter baumannii</i> Infections |
| title_sort | update on the therapeutic potential of antimicrobial peptides against i acinetobacter baumannii i infections |
| topic | AMP <i>Acinetobacter baumannii</i> resistance mechanism of action mechanism of action |
| url | https://www.mdpi.com/1424-8247/16/9/1281 |
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