The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report
Traumatic brain injury is a severe condition frequently complicated with infections, hypermetabolism, and augmented renal clearance (ARC). The ARC is a phenomenon characterized by increased creatinine clearance above 130 mL/min/1.73m2. This phenomenon has been associated with decreased blood concent...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Society of Anesthesiologists and Intensivists
2022-01-01
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| Series: | Serbian Journal of Anesthesia and Intensive Therapy |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2022/2217-77442201021M.pdf |
| _version_ | 1797997202935644160 |
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| author | Miljković Milijana Dragojević-Simić Viktorija Kovačević Aleksandra Stamenković Dušica Đurasinović Tatjana Kostić Dejan Rančić Nemanja |
| author_facet | Miljković Milijana Dragojević-Simić Viktorija Kovačević Aleksandra Stamenković Dušica Đurasinović Tatjana Kostić Dejan Rančić Nemanja |
| author_sort | Miljković Milijana |
| collection | DOAJ |
| description | Traumatic brain injury is a severe condition frequently complicated with infections, hypermetabolism, and augmented renal clearance (ARC). The ARC is a phenomenon characterized by increased creatinine clearance above 130 mL/min/1.73m2. This phenomenon has been associated with decreased blood concentrations of selected antibiotics, like vancomycin, probably causing treatment failure. Despite ARC's possible fatal consequences in our local medical community, it is rarely assessed. Patient with traumatic brain injury accompanied with secondary infection and augmented renal clearance accompanied with subtherapeutic vancomycin concentrations in the time of treatment is presented. Since concentrations of antibiotics are not routinely measured in Serbian hospitals, clinical practice adjustment and widely accepted method of antibiotics blood concentration measurement which is particularly important in critically ill patients is suggested. The clinical pharmacologist is a significant team member for the treatment of critically ill patients due to his/her expert knowledge of pharmacokinetics and drug interactions, especially important in this category of patients, contributing to positive clinical outcomes. |
| first_indexed | 2024-04-11T10:29:25Z |
| format | Article |
| id | doaj.art-88511f8839aa41a78886a825317c633f |
| institution | Directory Open Access Journal |
| issn | 2466-488X |
| language | English |
| last_indexed | 2024-04-11T10:29:25Z |
| publishDate | 2022-01-01 |
| publisher | Serbian Society of Anesthesiologists and Intensivists |
| record_format | Article |
| series | Serbian Journal of Anesthesia and Intensive Therapy |
| spelling | doaj.art-88511f8839aa41a78886a825317c633f2022-12-22T04:29:28ZengSerbian Society of Anesthesiologists and IntensivistsSerbian Journal of Anesthesia and Intensive Therapy2466-488X2022-01-01441-2212610.5937/sjait2202021M2217-77442201021MThe influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case reportMiljković Milijana0Dragojević-Simić Viktorija1https://orcid.org/0000-0003-1979-0762Kovačević Aleksandra2https://orcid.org/0000-0003-1743-2830Stamenković Dušica3https://orcid.org/0000-0003-4121-1966Đurasinović Tatjana4Kostić Dejan5Rančić Nemanja6https://orcid.org/0000-0002-5122-8094Military Medical Academy, Centre for Clinical Pharmacology, Belgrade, SerbiaMilitary Medical Academy, Centre for Clinical Pharmacology, Belgrade, SerbiaMilitary Medical Academy, Centre for Clinical Pharmacology, Belgrade, SerbiaUniversity of Defence, Military Medical Academy, Medical Faculty, Belgrade, SerbiaMilitary Medical Academy, Institute of Medical Biochemistry, Belgrade, SerbiaUniversity of Defence, Military Medical Academy, Medical Faculty, Belgrade, SerbiaMilitary Medical Academy, Centre for Clinical Pharmacology, Belgrade, SerbiaTraumatic brain injury is a severe condition frequently complicated with infections, hypermetabolism, and augmented renal clearance (ARC). The ARC is a phenomenon characterized by increased creatinine clearance above 130 mL/min/1.73m2. This phenomenon has been associated with decreased blood concentrations of selected antibiotics, like vancomycin, probably causing treatment failure. Despite ARC's possible fatal consequences in our local medical community, it is rarely assessed. Patient with traumatic brain injury accompanied with secondary infection and augmented renal clearance accompanied with subtherapeutic vancomycin concentrations in the time of treatment is presented. Since concentrations of antibiotics are not routinely measured in Serbian hospitals, clinical practice adjustment and widely accepted method of antibiotics blood concentration measurement which is particularly important in critically ill patients is suggested. The clinical pharmacologist is a significant team member for the treatment of critically ill patients due to his/her expert knowledge of pharmacokinetics and drug interactions, especially important in this category of patients, contributing to positive clinical outcomes.https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2022/2217-77442201021M.pdftraumatic brain injuriesaugmented renal clearancevancomycinpharmacokinetic |
| spellingShingle | Miljković Milijana Dragojević-Simić Viktorija Kovačević Aleksandra Stamenković Dušica Đurasinović Tatjana Kostić Dejan Rančić Nemanja The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report Serbian Journal of Anesthesia and Intensive Therapy traumatic brain injuries augmented renal clearance vancomycin pharmacokinetic |
| title | The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report |
| title_full | The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report |
| title_fullStr | The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report |
| title_full_unstemmed | The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report |
| title_short | The influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury: Case report |
| title_sort | influence of augmented renal clearance on vancomycin blood concentrations in patients with traumatic brain injury case report |
| topic | traumatic brain injuries augmented renal clearance vancomycin pharmacokinetic |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2217-7744/2022/2217-77442201021M.pdf |
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