BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors

BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors

Background Mismatch repair deficiency (dMMR) is a well-recognized biomarker for response to immune checkpoint blockade (ICB). Strategies to convert MMR-proficient (pMMR) to dMMR phenotype with the goal of sensitizing tumors to ICB are highly sought. The combination of bromodomain containing 4 (BRD4)...

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Bibliographic Details
Main Authors: Li Zhang, Xi Li, Gang Chen, Yu Fu, Bin Yang, Wenting Li, Jingbo Liu, Xu Qin, Gordon B Mills, Yaoyuan Cui, Xingyuan Hu, Funian Lu, Tianyu Qin, Zhe Hu, Ensong Guo, Junpeng Fan, Rourou Xiao, Dianxing Hu, Wenju Peng, Beibei Wang, Chaoyang Sun
Format: Article
Language:English
Published: BMJ Publishing Group 2023-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/4/e006070.full

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