Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma
Background: Pancreatic ductal adenocarcinoma differs from other solid tumors with its unique immunosuppressive microenvironment and non-immunogenic feature. There are not many studies in the literature investigating the effect of these features on prognosis. Aims: To investigate the prognostic valu...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2022-01-01
|
| Series: | Balkan Medical Journal |
| Online Access: | https://balkanmedicaljournal.org/text.php?lang=en&id=2349 |
| _version_ | 1797912930549760000 |
|---|---|
| author | Tuğba Başoğlu Kadriye Ebru Akar Pelin Bağcı Nalan Akgül Babacan Mehmet Akif Öztürk Fatih Emin Öztürk Nazım Can Demircan Rukiye Arıkan Tuğba Akın Telli Özlem Ercelep Faysal Dane Perran Fulden Yumuk |
| author_facet | Tuğba Başoğlu Kadriye Ebru Akar Pelin Bağcı Nalan Akgül Babacan Mehmet Akif Öztürk Fatih Emin Öztürk Nazım Can Demircan Rukiye Arıkan Tuğba Akın Telli Özlem Ercelep Faysal Dane Perran Fulden Yumuk |
| author_sort | Tuğba Başoğlu |
| collection | DOAJ |
| description | Background: Pancreatic ductal adenocarcinoma differs from other solid tumors with its unique immunosuppressive microenvironment and non-immunogenic feature. There are not many studies in the literature investigating the effect of these features on prognosis.
Aims: To investigate the prognostic value of tissue-resident memory
T cells, tumor microenvironment features, and tumor-associated immune cells in resected pancreatic ductal adenocarcinomas.
Study Design: Retrospective cross-sectional study.
Methods: Of 138 patients diagnosed with pancreatic ductal adenocarcinoma between 2011 and 2018, 81 were included in the study. Specimens from operated patients were reassessed separately as peritumoral and intratumoral areas for tissue resident memory cells and tumor microenvironmental elements (tumor infiltrating lymphocytes, tumor stroma, CD204+ macrophages, PDL1+ immune cells). Disease-free survival and overall survival were defined from the date of operation to the date of recurrence and the date of first diagnosis to the date of death, respectively. If the patient was alive, the last visit date was taken into account.
Results: The median age at diagnosis was 63 (range: 40-78). The median follow-up period was 18.9 months (range: 1.4-80.4 months). Median overall survival was 23.7 months (1.4-80.4 months) and median disease-free survival was 10.8 months (1.4-74.4 months).
Patients with higher intra-tumoral tissue-resident memory cell counts had a longer survival trend than those having lower values (25.6 months vs. 18 months, respectively, P = .84). According to microenvironmental evaluations, lower stromal score (defined as stroma having less desmoplasia and rich in cells) and presence of peritumoral Crohn’s-like inflammatory response were associated with higher survival (29.2 months vs. 19.7 months for low vs. high stromal scores, respectively, P = .16 and 30.2 months vs. 18.1 months for the presence of Crohn’s-like inflammatory response P = .13). Decreased survival was observed in tumors with increased CD204+ tumor-associated macrophages which were immunosuppressive elements of the microenvironment (12 months vs. 26.3 months for intra-tumoral assessment, P = .29).
Conclusion: Tissue-resident memory T cells and other microenvironmental features may be prognostic in resectable pancreatic ductal adenocarcinomas. Further studies with larger cohorts are needed for validation. |
| first_indexed | 2024-04-10T12:03:43Z |
| format | Article |
| id | doaj.art-8851ad7ecb0946b8a21314805e33eb05 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:03:43Z |
| publishDate | 2022-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-8851ad7ecb0946b8a21314805e33eb052023-02-15T16:16:22ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312022-01-01391122010.5152/balkanmedj.2021.21122Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic AdenocarcinomaTuğba Başoğlu0https://orcid.org/0000-0002-2059-5502Kadriye Ebru Akar1https://orcid.org/0000-0003-1512-1166Pelin Bağcı2https://orcid.org/0000-0002-6656-8227Nalan Akgül Babacan3https://orcid.org/0000-0001-6006-4290Mehmet Akif Öztürk4https://orcid.org/0000-0003-1365-7944Fatih Emin Öztürk5https://orcid.org/0000-0002-8075-7307Nazım Can Demircan6https://orcid.org/0000-0001-6630-5278Rukiye Arıkan7https://orcid.org/0000-0003-2688-1515Tuğba Akın Telli8https://orcid.org/0000-0001-6535-6030Özlem Ercelep9https://orcid.org/0000-0001-5892-3519Faysal Dane10https://orcid.org/0000-0001-6584-902XPerran Fulden Yumuk11https://orcid.org/0000-0001-8650-299XDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Pathology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Pathology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Bahrain Oncology Center, Al Sayh, BahrainDepartment of Medical Oncology, Bahçeşehir University School of Medicine, İstanbul, TurkeyDepartment of Internal Medicine, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyDepartment of Medical Oncology, Marmara University School of Medicine, İstanbul, TurkeyBackground: Pancreatic ductal adenocarcinoma differs from other solid tumors with its unique immunosuppressive microenvironment and non-immunogenic feature. There are not many studies in the literature investigating the effect of these features on prognosis. Aims: To investigate the prognostic value of tissue-resident memory T cells, tumor microenvironment features, and tumor-associated immune cells in resected pancreatic ductal adenocarcinomas. Study Design: Retrospective cross-sectional study. Methods: Of 138 patients diagnosed with pancreatic ductal adenocarcinoma between 2011 and 2018, 81 were included in the study. Specimens from operated patients were reassessed separately as peritumoral and intratumoral areas for tissue resident memory cells and tumor microenvironmental elements (tumor infiltrating lymphocytes, tumor stroma, CD204+ macrophages, PDL1+ immune cells). Disease-free survival and overall survival were defined from the date of operation to the date of recurrence and the date of first diagnosis to the date of death, respectively. If the patient was alive, the last visit date was taken into account. Results: The median age at diagnosis was 63 (range: 40-78). The median follow-up period was 18.9 months (range: 1.4-80.4 months). Median overall survival was 23.7 months (1.4-80.4 months) and median disease-free survival was 10.8 months (1.4-74.4 months). Patients with higher intra-tumoral tissue-resident memory cell counts had a longer survival trend than those having lower values (25.6 months vs. 18 months, respectively, P = .84). According to microenvironmental evaluations, lower stromal score (defined as stroma having less desmoplasia and rich in cells) and presence of peritumoral Crohn’s-like inflammatory response were associated with higher survival (29.2 months vs. 19.7 months for low vs. high stromal scores, respectively, P = .16 and 30.2 months vs. 18.1 months for the presence of Crohn’s-like inflammatory response P = .13). Decreased survival was observed in tumors with increased CD204+ tumor-associated macrophages which were immunosuppressive elements of the microenvironment (12 months vs. 26.3 months for intra-tumoral assessment, P = .29). Conclusion: Tissue-resident memory T cells and other microenvironmental features may be prognostic in resectable pancreatic ductal adenocarcinomas. Further studies with larger cohorts are needed for validation.https://balkanmedicaljournal.org/text.php?lang=en&id=2349 |
| spellingShingle | Tuğba Başoğlu Kadriye Ebru Akar Pelin Bağcı Nalan Akgül Babacan Mehmet Akif Öztürk Fatih Emin Öztürk Nazım Can Demircan Rukiye Arıkan Tuğba Akın Telli Özlem Ercelep Faysal Dane Perran Fulden Yumuk Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma Balkan Medical Journal |
| title | Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma |
| title_full | Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma |
| title_fullStr | Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma |
| title_full_unstemmed | Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma |
| title_short | Prognostic Value of Tissue-Resident Memory T Cells and Tumor Microenvironmental Features in Resected Pancreatic Adenocarcinoma |
| title_sort | prognostic value of tissue resident memory t cells and tumor microenvironmental features in resected pancreatic adenocarcinoma |
| url | https://balkanmedicaljournal.org/text.php?lang=en&id=2349 |
| work_keys_str_mv | AT tugbabasoglu prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT kadriyeebruakar prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT pelinbagcı prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT nalanakgulbabacan prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT mehmetakifozturk prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT fatiheminozturk prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT nazımcandemircan prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT rukiyearıkan prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT tugbaakıntelli prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT ozlemercelep prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT faysaldane prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma AT perranfuldenyumuk prognosticvalueoftissueresidentmemorytcellsandtumormicroenvironmentalfeaturesinresectedpancreaticadenocarcinoma |