Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation
The biomarker potential of using various lipids fractions for predicting risk of acute myocardial infarction (AMI) is controversial. We therefore compared the lipid profiles, including serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL)...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-01-01
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| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S11015 |
| _version_ | 1818516580862001152 |
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| author | Haseeb A. Khan Abdullah S. Alhomida Samia H. Sobki |
| author_facet | Haseeb A. Khan Abdullah S. Alhomida Samia H. Sobki |
| author_sort | Haseeb A. Khan |
| collection | DOAJ |
| description | The biomarker potential of using various lipids fractions for predicting risk of acute myocardial infarction (AMI) is controversial. We therefore compared the lipid profiles, including serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL) and triglycerides (TG), in 67 AMI patients. Patients included 28 STEMI (ST-elevated myocardial infarction) patients, 39 NSTEMI (non-ST-elevated myocardial infarction) patients and 25 patients with chest pain. Control group included 54 age- and gender-matched normal subjects. We also studied the correlation between lipid profile and systemic inflammation in these subjects. There were significant decreases in TC, LDL and HDL levels in both STEMI and NSTEMI patients as compared to normal subjects; however, patients with chest pain did not show any significant change in these lipids. Serum TG levels did not differ significantly among the study groups. There were significant increases in serum high-sensitive C-reactive protein (hs-CRP) levels in STEMI and NSTEMI patients, as compared to control group. Serum hs-CRP showed significant inverse correlation with HDL; however, hs-CRP was not correlated with TC, LDL, and TG. In conclusion, our findings suggest that reduction in serum TC does not prevent the risk of AMI, whereas a decrease in serum HDL and increase in hs-CRP strongly predisposes the risky individuals to an AMI event. We emphasize the importance of HDL and CRP measurements for the assessment of a combined lipid-inflammation risk factor that could be a useful predictor of high risk individuals, as well as a prognostic marker in AMI patients. |
| first_indexed | 2024-12-11T00:44:13Z |
| format | Article |
| id | doaj.art-8851cd03197b4e74862a744892159190 |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-11T00:44:13Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-8851cd03197b4e74862a7448921591902022-12-22T01:26:50ZengSAGE PublishingBiomarker Insights1177-27192013-01-01810.4137/BMI.S11015Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic InflammationHaseeb A. Khan0Abdullah S. Alhomida1Samia H. Sobki2Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.Division of Clinical Biochemistry, Department of Pathology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.The biomarker potential of using various lipids fractions for predicting risk of acute myocardial infarction (AMI) is controversial. We therefore compared the lipid profiles, including serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL) and triglycerides (TG), in 67 AMI patients. Patients included 28 STEMI (ST-elevated myocardial infarction) patients, 39 NSTEMI (non-ST-elevated myocardial infarction) patients and 25 patients with chest pain. Control group included 54 age- and gender-matched normal subjects. We also studied the correlation between lipid profile and systemic inflammation in these subjects. There were significant decreases in TC, LDL and HDL levels in both STEMI and NSTEMI patients as compared to normal subjects; however, patients with chest pain did not show any significant change in these lipids. Serum TG levels did not differ significantly among the study groups. There were significant increases in serum high-sensitive C-reactive protein (hs-CRP) levels in STEMI and NSTEMI patients, as compared to control group. Serum hs-CRP showed significant inverse correlation with HDL; however, hs-CRP was not correlated with TC, LDL, and TG. In conclusion, our findings suggest that reduction in serum TC does not prevent the risk of AMI, whereas a decrease in serum HDL and increase in hs-CRP strongly predisposes the risky individuals to an AMI event. We emphasize the importance of HDL and CRP measurements for the assessment of a combined lipid-inflammation risk factor that could be a useful predictor of high risk individuals, as well as a prognostic marker in AMI patients.https://doi.org/10.4137/BMI.S11015 |
| spellingShingle | Haseeb A. Khan Abdullah S. Alhomida Samia H. Sobki Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation Biomarker Insights |
| title | Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation |
| title_full | Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation |
| title_fullStr | Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation |
| title_full_unstemmed | Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation |
| title_short | Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation |
| title_sort | lipid profile of patients with acute myocardial infarction and its correlation with systemic inflammation |
| url | https://doi.org/10.4137/BMI.S11015 |
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