Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study
Objectives In the early stage of sepsis, identifying high-risk paediatric patients with a poor prognosis and providing timely and adequate treatment are critical. This study aimed to evaluate the effect of average body temperature within 24 hours of admission on the short-term prognosis of paediatri...
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| Format: | Article |
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BMJ Publishing Group
2023-04-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/4/e067716.full |
| _version_ | 1797845005588496384 |
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| author | Lei Han Huabin Wang Yanhua Chang Meiyun Xin Tongshu Hou Ruipin Zhang Ziying Liu Bing Sun Lijun Gan |
| author_facet | Lei Han Huabin Wang Yanhua Chang Meiyun Xin Tongshu Hou Ruipin Zhang Ziying Liu Bing Sun Lijun Gan |
| author_sort | Lei Han |
| collection | DOAJ |
| description | Objectives In the early stage of sepsis, identifying high-risk paediatric patients with a poor prognosis and providing timely and adequate treatment are critical. This study aimed to evaluate the effect of average body temperature within 24 hours of admission on the short-term prognosis of paediatric patients with sepsis.Design A retrospective cohort study.Setting A single-centre, tertiary care hospital in China, containing patient data from 2010 to 2018.Participants 1144 patients with sepsis were included.Intervention None.Primary and secondary outcome measures The main outcome measure was in-hospital mortality, which was defined as death from any cause during hospitalisation. The secondary outcome was the length of hospital stay.Results The LOWESS method showed a roughly ‘U’-shaped relationship between body temperature on the first day and in-hospital mortality. Multivariate logistic regression showed that severe hypothermia (OR 14.72, 95% CI 4.84 to 44.75), mild hypothermia (OR 3.71, 95% CI 1.26 to 10.90), mild hyperthermia (OR 3.41, 95% CI 1.17 to 9.90) and severe hyperthermia (OR 5.15, 95% CI 1.84 to 14.43) were independent risk factors for in-hospital mortality. Compared with other variables, the Wald χ2 value of temperature on the first day minus the degree of freedom was the highest.Conclusions Whether hypothermic or hyperthermic, the more abnormal the temperature on the first day is, the higher the risk of in-hospital death in children with sepsis. |
| first_indexed | 2024-04-09T17:31:35Z |
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| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-09T17:31:35Z |
| publishDate | 2023-04-01 |
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| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-8851e0b909434596a219b6f05440c9592023-04-18T04:30:06ZengBMJ Publishing GroupBMJ Open2044-60552023-04-0113410.1136/bmjopen-2022-067716Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective studyLei Han0Huabin Wang1Yanhua Chang2Meiyun Xin3Tongshu Hou4Ruipin Zhang5Ziying Liu6Bing Sun7Lijun Gan8The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, People`s Republic of ChinaDepartment of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, People`s Republic of ChinaDepartment of Pediatric Intensive Care Unit, Affiliated Hospital of Jining Medical University, Jining, People`s Republic of ChinaThe Second Medical College, Binzhou Medical University, Yantai, People`s Republic of ChinaDepartment of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, People`s Republic of ChinaDepartment of Pediatrics, Affiliated Hospital of Jining Medical University, Jining, People`s Republic of ChinaCollege of Integrated Traditional Chinese and Westen Medicine, Jining Medical University, Jining, People`s Republic of ChinaDepartment of Cardiology, Affiliated Hospital of Jining Medical University, Jining, People`s Republic of ChinaObjectives In the early stage of sepsis, identifying high-risk paediatric patients with a poor prognosis and providing timely and adequate treatment are critical. This study aimed to evaluate the effect of average body temperature within 24 hours of admission on the short-term prognosis of paediatric patients with sepsis.Design A retrospective cohort study.Setting A single-centre, tertiary care hospital in China, containing patient data from 2010 to 2018.Participants 1144 patients with sepsis were included.Intervention None.Primary and secondary outcome measures The main outcome measure was in-hospital mortality, which was defined as death from any cause during hospitalisation. The secondary outcome was the length of hospital stay.Results The LOWESS method showed a roughly ‘U’-shaped relationship between body temperature on the first day and in-hospital mortality. Multivariate logistic regression showed that severe hypothermia (OR 14.72, 95% CI 4.84 to 44.75), mild hypothermia (OR 3.71, 95% CI 1.26 to 10.90), mild hyperthermia (OR 3.41, 95% CI 1.17 to 9.90) and severe hyperthermia (OR 5.15, 95% CI 1.84 to 14.43) were independent risk factors for in-hospital mortality. Compared with other variables, the Wald χ2 value of temperature on the first day minus the degree of freedom was the highest.Conclusions Whether hypothermic or hyperthermic, the more abnormal the temperature on the first day is, the higher the risk of in-hospital death in children with sepsis.https://bmjopen.bmj.com/content/13/4/e067716.full |
| spellingShingle | Lei Han Huabin Wang Yanhua Chang Meiyun Xin Tongshu Hou Ruipin Zhang Ziying Liu Bing Sun Lijun Gan Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study BMJ Open |
| title | Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study |
| title_full | Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study |
| title_fullStr | Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study |
| title_full_unstemmed | Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study |
| title_short | Hypothermia or hyperthermia, which is associated with patient outcomes in critically ill children with sepsis? —A retrospective study |
| title_sort | hypothermia or hyperthermia which is associated with patient outcomes in critically ill children with sepsis a retrospective study |
| url | https://bmjopen.bmj.com/content/13/4/e067716.full |
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