Pharmacokinetic/Pharmacodynamic Integration to Evaluate the Changes in Susceptibility of Actinobacillus pleuropneumoniae After Repeated Administration of Danofloxacin

Pharmacokinetic/Pharmacodynamic Integration to Evaluate the Changes in Susceptibility of Actinobacillus pleuropneumoniae After Repeated Administration of Danofloxacin

To evaluate the relationship between pharmacokinetic/pharmacodynamic (PK/PD) parameters and changes in susceptibility and resistance frequency of Actinobacillus pleuropneumoniae CVCC 259, a piglet tissue cage (TC) infection model was established. After A. pleuropneumoniae populations maintained at 1...

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Bibliographic Details
Main Authors: Longfei Zhang, Zheng Kang, Lihua Yao, Xiaoyan Gu, Zilong Huang, Qinren Cai, Xiangguang Shen, Huanzhong Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
PK/PD
mutant frequency
danofloxacin
Actinobacillus pleuropneumoniae
tissue cage infection model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02445/full

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